Following its evolution from the question of “how to translate knowledge” to that of “how translation produces knowledge”, Transknowletology now urgently needs to address the question of where the human stands. Constructing the theoretical framework of “Translation-Knowledge-Human-Action” and elucidating the connotations of “understanding translation through knowledge”, “translation for the sake of knowledge”, “translation for humanization”, “true knowledge achieves true humanity”, and “the unity of knowledge and action” is not only key to answering for whom translation ultimately exists, but is also integral to affecting a humanistic turn in Transknowletology itself. This endeavor systematically articulates the proposition of “Knowledge as Materialism and Translation as Humanism”. Moreover, in confronting the contemporary condition of inter-knowledgeness, it demonstrates the theoretical tension of Transknowletology in fostering epistemic equality and mutual learning among civilizations.