目的：检测成人Epstein-Barr病毒（EB病毒）感染患者的EB病毒相关抗体及EB病毒DNA、血常规、血生化指标,对其临床症状进行分析,探讨成人EB病毒感染的临床特点。方法：收集67例成人EB病毒感染患者的临床资料及实验室检测结果,并将其按年龄分为青中年组（18~59岁,19例）和老年组（≥60岁,48例）;另收集同期的49名健康体检者,按前述年龄分为2组,分别作为年龄对照组。分析成人EB病毒感染的临床特点及不同年龄段患者间的异同。结果：67例成人EB病毒感染患者中,最常见的症状为发热（37例,55.2%）;其次为淋巴结肿大（13例,19.4%）、脾肿大（9例,13.4%）、肝脏肿大（8例,11.9%）、咽部充血（6例,9.0%）和皮疹（5例,7.5%）。EB病毒感染的青中年患者与老年患者相比较,发热（84.2%比43.8%）、咽部充血（26.3%比2.1%）、皮疹（21.1%比2.1%）、肝脏肿大（31.6%比4.2%）的临床症状明显（χ²值分别为9.012、7.057、4.612、7.295,P均<0.05）。19例青中年患者中有2例伴发恶性肿瘤性疾病;而48例老年患者中有2例（4.1%）伴发嗜血细胞淋巴组织细胞增生症,17例（34.7%）伴发恶性肿瘤性疾病,2组间的恶性肿瘤患病构成比差异有统计学意义（χ²=4.15,P=0.042）。EB病毒感染老年组的T淋巴细胞总数、CD4⁺T淋巴细胞计数、B淋巴细胞计数均低于健康老年组（t分别为4.525,5.960,2.999,P均<0.05）,而EB病毒感染青中年组的淋巴细胞亚群数与健康青中年组比较,差异无统计学意义（P>0.05）。青中年EB病毒感染患者与老年患者比较,EB病毒相关抗体表达水平及肝功能指标差异无统计学意义（P均>0.05）。结论：成人EB病毒感染患者的临床表现各异,青中年患者的急性感染症状较老年患者明显,而老年患者的细胞免疫及体液免疫功能降低,且EB病毒相关肿瘤患病者构成比高。

Objective: To study the clinical characteristics of Epstein-Barr virus(EB virus) infection in adult patients by detecting EB virus-associated antibodies, EB virus DNA, blood routine, blood biochemistry and analyzing clinical symptoms. Methods: A total of 67 adults with EB virus infection were enrolled. Patients were divided into two age groups:young and middle-aged group (18-59 years old, 19 cases) and elderly group (60 years old and above, 48 cases), and 49 healthy subjects including 30 young and middle-aged and 19 elderly people were served as aged group controls. The clinical characteristics of EB virus infection were studied and the differences between the two age groups were compared. Results: Fever was the most common presenting symptom (37 cases, 55.2%), and followed by enlarged lymph nodes(13 cases,19.4%), splenomegaly (9 cases,13.4%), liver enlargement(8 cases, 11.9%), pharyngeal congestion (6 cases, 9.0%), and rash (5 cases, 7.5%). Fever (84.2% vs 43.8%), pharyngeal congestion (26.3% vs 2.1%), rash (21.1% vs 2.1%), liver enlargement (31.6 % vs 4.2%) in young and middle-aged patients were more common than in elderly group ( χ² values: 9.012, 7.057, 4.612, 7.295, P<0.05). Two cases in young and middle-aged group had malignant tumor diseases (10.5%), while 2 cases (4.1%) in elderly group had hematopoietic lymphohistiocytosis and 17 cases (34.7 %) had malignant tumor diseases. The constituent ratio of cases with malignant tumor diseases between the two groups was significantly different ( χ²=4.15, P=0.042). The total number of T lymphocytes, count of CD4 ⁺ T lymphocytes, and B lymphocytes in the elderly group were lower than those in the healthy control group (t=4.525, 5.960, 2.999, P all <0.05), while the number of lymphocyte subsets in the young and middle-aged group was not significantly different from that in the healthy controls(P>0.05). There were no statistical differences in liver function indices and levels of EB virus-related antibodies between young and middle-aged and elderly patients(P>0.05). Conclusions: Clinical manifestations of EB virus infection in adults are varied. The symptoms of acute infection are more common in young and middle-aged patients than in the elderly patients. The cellular immunity and humoral immunity are decreased in elderly patients, and the constituent ratio of cases with EB virus-related tumors is high.