目的：研究上海市宝山区淞南社区常住中老年人群的静息心率与糖尿病发病风险间的相关性。方法：采取整群抽样的方法,对上海市宝山区淞南社区共4 012名40岁及以上的常住居民进行调查。对每位受试者进行标准化问卷调查、体格检查,并采集其空腹及餐后血检测血糖、血脂等生化指标。将4 012名研究对象按心率的五分位分为5组,以第一分位组为对照组,采用Logistic回归模型分析其余各心率组间的糖尿病患病风险。结果：上海市宝山区淞南社区常住中老年人群的糖尿病患病率随其静息心率升高而上升（P<0.000 1）,从心率第一分位组到第五分位组的糖尿病患病率分别为22.94%、27.77%、31.94%、37.21%、46.76%。该人群的静息心率水平与空腹血糖、2 h血糖水平及稳态模型评估的胰岛素抵抗指数呈正相关（均P<0.001）。多元Logistic回归分析结果显示,在校正其他传统危险因素后,静息心率第五分位组的糖尿病患病风险比第一分位组增加1.77倍[比值比(OR)=2.77,95%可信区间（confidence interval,CI）为2.18~3.51]。结论：上海市宝山区淞南社区常住中老年人群的静息心率水平升高与其糖尿病患病风险升高相关,提示在今后的临床工作中对于高水平心率人群需进行适当监督,早期筛查血糖。
吴雪妍, 马丽娜, 程棣, 杜瑞, 徐瑜, 徐敏, 陆洁莉, 陈宇红, 毕宇芳, 王卫庆, 高金丽, 钱晓忠
. 上海市宝山区淞南社区中老年人群静息心率与糖尿病相关性的流行病学调查[J]. 诊断学理论与实践, 2018
, 17(01)
: 45
-50
.
DOI: 10.16150/j.1671-2870.2018.01.008
Objective: To investigate the relationship between resting heart rate and diabetes mellitus in a community-based study among middle-aged and elderly population. Methods: A survey of 4 012 subjects aged 40 years or older in Songnan community of Shanghai Baoshan District was performed using cluster sampling. All the individuals recruited underwent questionnaire interview and anthropometric measurements. Blood samples were collected to measure biochemical indices, including fasting blood glucose, 2 h postprandial blood glucose and lipid profiles. Diabetes mellitus was diagnosed according to the World Health Organization criteria in 2006. Participants were divided into 5 groups by resting heart rate quintiles. Logistic regression analysis was used to analyze the risk of diabetes among people with different resting heart rate levels. Results: The prevalence of diabetes was increased from quintile 1 to quintile 5: 22.94%,27.77%,31.94%,37.21%,46.76% (P<0.0001). Resting heart rate level was positively correlated with fasting blood glucose, 2-h postprandial blood glucose, and homeostasis model assessment for insulin resistance (all P<0.001). After adjustment for other conventional risk factors, those in the quintile 5 group had 1.77 folds higher risk of diabetes mellitus when compared with individuals in the quintile 1 group [odds ratio (OR)=2.77, 95% confidence interval (CI): 2.18-3.51]. Conclusions: In the middle-aged and elderly population, a high-normal resting heart rate level is associated with an increased risk of diabetes mellitus, suggesting that we should monitor the participants who have high level of heart rate.
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