目的： 分析上海市松江地区女性人乳头瘤病毒（human papillomavirus, HPV）感染及其亚型分布的情况,为预防HPV感染提供理论依据。方法： 本研究使用基因芯片检测技术,对52 973例妇科门诊患者进行HPV亚型检测。结果： 结果提示共计12 139例患者感染HPV,感染率为22.92%,共检出HPV 16 637株,其中高危型HPV占78.61%。感染率最高的5种HPV亚型依次为16、58、52、51、68型,均为高危型。单一亚型病毒感染的患者有8 933例,占总HPV感染者的73.50%,单一亚型感染者中又以高危亚型感染为主（占80.48%）;多重亚型感染者共有3 206例（26.50%）,其中以二重感染为主,而二重感染患者又以单纯高危型感染为主（占57.71%）,常见的感染亚型组合为HPV16型和58型。≤20岁、21~30岁、31~40岁、41~50岁、51~60岁、≥61岁年龄组的HPV感染率分别为31.83%、21.48%、20.66%、23.69%、30.35%、33.88%。结论： 松江地区妇科门诊患者的HPV总感染率为22.92%,其中最常见的HPV亚型为16、58、52、51、68型,患者以单一亚型感染为主,以高危亚型常见,而发生二重感染的患者以单纯高危亚型感染多见,60岁以上的妇科门诊患者的HPV感染率较高。

Objective: To analyze the distribution of human papilloma virus (HPV) infection and subtypes in Songjiang District, Shanghai for providing a theoretical basis for prevention of HPV infection. Method: A total of 52 973 gynecological outpatients tested for HPV subtypes by gene chip detection were enrolled in this study. Result: A total of 12 139 patients were infected with HPV. The HBV infection rate was 22.92%. Altogether 16 637 strains of human papilloma virus were detected, and high-risk HPV subtypes accounted for 78.61%. The top five infection subtypes were: HPV16, 58, 52, 51, 68, all of which were high-risk subtypes. Of the infected patients, 8 933 cases were single infection (73.50%), mainly with high-risk subtypes, accounting for 80.48%; 3 206 cases were multiple infection (26.50%), most of which were double infection with high-risk subtype (57.71%), and the common ones were HPV16 and 58. The infection rates of ≤20 years old, 21-30 years old, 31-40 years old, 41-50 years old, 51-60 years old, ≥61 years old groups were 31.83%, 21.48%, 20.66%, 23.69%, 30.35%, 33.88%, respectively. Conclusions: In Songjiang District, HPV infection rate among gynecological outpatients was 22.92%. The most common HPV subtypes were 16, 58, 52, 51, 68. The majority is single infection, and most of which with high-risk subtypes. Among double infection, most were high-risk subtype combination. The age group ≥60 years shows higher infection rate.