诊断学理论与实践

诊断学理论与实践 ›› 2019, Vol. 18 ›› Issue (04): 460-465.doi: 10.16150/j.1671-2870.2019.04.015

• 论著 • 上一篇    下一篇

上海市松江地区2016年到2017年52 973例妇科门诊患者人乳头瘤病毒亚型感染情况分析

王宏1, 黄路遥2, 杨翌翔2()   

  1. 1.上海市松江区九亭医院检验科, 上海 2016152
    2.上海市松江区中心医院检验科,上海201600
  • 收稿日期:2019-06-01 出版日期:2019-08-25 发布日期:2019-08-25
  • 通讯作者: 杨翌翔 E-mail:yyx1024@vip.qq.com
  • 基金资助:
    上海市松江区科学技术攻关项目(16SJGG45)

Study on human papillomavirus infection in gynecological outpatients in Songjiang District during 2016 to 2017

WANG HONG1, HUANG Luyao2, YANG Yixiang2()   

  1. 1. Department of Laboratory, Jiu Ting Hospital of Songjiang District, Shanghai 201615, China
    2. Department of Laboratory,Central Hospital of Songjiang District,Shanghai 201600, China
  • Received:2019-06-01 Online:2019-08-25 Published:2019-08-25
  • Contact: YANG Yixiang E-mail:yyx1024@vip.qq.com

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摘要：

目的： 分析上海市松江地区女性人乳头瘤病毒（human papillomavirus, HPV）感染及其亚型分布的情况,为预防HPV感染提供理论依据。方法： 本研究使用基因芯片检测技术,对52 973例妇科门诊患者进行HPV亚型检测。结果： 结果提示共计12 139例患者感染HPV,感染率为22.92%,共检出HPV 16 637株,其中高危型HPV占78.61%。感染率最高的5种HPV亚型依次为16、58、52、51、68型,均为高危型。单一亚型病毒感染的患者有8 933例,占总HPV感染者的73.50%,单一亚型感染者中又以高危亚型感染为主（占80.48%）;多重亚型感染者共有3 206例（26.50%）,其中以二重感染为主,而二重感染患者又以单纯高危型感染为主（占57.71%）,常见的感染亚型组合为HPV16型和58型。≤20岁、21~30岁、31~40岁、41~50岁、51~60岁、≥61岁年龄组的HPV感染率分别为31.83%、21.48%、20.66%、23.69%、30.35%、33.88%。结论： 松江地区妇科门诊患者的HPV总感染率为22.92%,其中最常见的HPV亚型为16、58、52、51、68型,患者以单一亚型感染为主,以高危亚型常见,而发生二重感染的患者以单纯高危亚型感染多见,60岁以上的妇科门诊患者的HPV感染率较高。

关键词: 人乳头瘤病毒, 亚型, 感染

Abstract:

Objective: To analyze the distribution of human papilloma virus (HPV) infection and subtypes in Songjiang District, Shanghai for providing a theoretical basis for prevention of HPV infection. Method: A total of 52 973 gynecological outpatients tested for HPV subtypes by gene chip detection were enrolled in this study. Result: A total of 12 139 patients were infected with HPV. The HBV infection rate was 22.92%. Altogether 16 637 strains of human papilloma virus were detected, and high-risk HPV subtypes accounted for 78.61%. The top five infection subtypes were: HPV16, 58, 52, 51, 68, all of which were high-risk subtypes. Of the infected patients, 8 933 cases were single infection (73.50%), mainly with high-risk subtypes, accounting for 80.48%; 3 206 cases were multiple infection (26.50%), most of which were double infection with high-risk subtype (57.71%), and the common ones were HPV16 and 58. The infection rates of ≤20 years old, 21-30 years old, 31-40 years old, 41-50 years old, 51-60 years old, ≥61 years old groups were 31.83%, 21.48%, 20.66%, 23.69%, 30.35%, 33.88%, respectively. Conclusions: In Songjiang District, HPV infection rate among gynecological outpatients was 22.92%. The most common HPV subtypes were 16, 58, 52, 51, 68. The majority is single infection, and most of which with high-risk subtypes. Among double infection, most were high-risk subtype combination. The age group ≥60 years shows higher infection rate.

Key words: Human papillomavirus (HPV), Subtype, Infection

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