收稿日期: 2019-08-22
网络出版日期: 2022-07-14
基金资助
国家自然科学基金重大研究计划(91639203);上海市自然科学基金面上项目(19DZ2340200)
Accuracy of home versus ambulatory blood pressure monitoring in the diagnosis of white-coat and masked hypertension
Received date: 2019-08-22
Online published: 2022-07-14
目的: 探究家庭血压测量和24 h动态血压(以下称动态血压)监测诊断白大衣高血压及隐匿性高血压的准确性。方法: 研究对象为全国多中心动态血压及家庭血压登记研究中上海地区的受试者,均接受动态血压监测,并进行了诊室血压测量和7 d家庭血压测量。本组总计纳入1 067例患者,平均年龄为57.5岁,男性占39.9%。依据相关高血压指南,白大衣高血压定义为诊室测平均收缩压≥140 mmHg和(或)平均收缩压≥90 mmHg,而动态血压监测正常(平均收缩压<130 mmHg且平均舒张压<80 mmHg)或家庭血压测量正常(平均收缩压<135 mmHg且平均舒张压<85 mmHg);隐匿性高血压为诊室测量血压正常而动态血压升高或家庭血压升高。结果: 在1 067例患者中,接受降压药物治疗的高血压患者为867例,未治疗患者200例。在未治疗患者中,动态血压监测和家庭血压测量诊断白大衣高血压的患病率分别为10.0%和17.0%(P=0.04),动态血压监测和家庭血压测量诊断隐匿性高血压的患病率分别为26.5%和14.5%(P=0.003)。以动态血压监测为标准,无论未治疗患者还是治疗患者,家庭血压测量诊断白大衣及隐匿性高血压的灵敏度都较低(43%~86%),特异度较高(91%~99%),阳性预测值较低(46%~91%),阴性预测值较高(84%~100%)。动态血压监测与家庭血压测量间的诊断一致性为81%~90%,Kappa值为0.43到0.78。结论: 家庭血压测量诊断白大衣及隐匿性高血压的灵敏度较低,但特异度较高。因此,尽管家庭血压测量不能替代动态血压监测,但可作为其有益的补充。
李宙童, 张炜, 王继光 . 家庭血压测量诊断白大衣高血压及隐匿性高血压的准确性研究[J]. 诊断学理论与实践, 2020 , 19(05) : 487 -493 . DOI: 10.16150/j.1671-2870.2020.05.008
Objective: To investigate accuracy of home blood pressure (BP) monitoring in the diagnosis of white-coat and masked hypertension in comparison with ambulatory BP monitoring. Methods: Participants were patients enrolled in the China Ambulatory and Home BP Registry, and underwent clinic, home, and 24 h ambulatory BP measurements. White-coat hypertension was defined as an elevated clinic systolic/diastolic BP (≥140/90 mmHg) and a normal 24 h ambulatory (<130/80 mmHg) or home systolic/diastolic BP (<135/85 mmHg), while masked hypertension as a normal clinic systolic/diastolic BP (<140/90 mmHg) and an elevated 24 h ambulatory (≥130/80 mmHg) or home systolic/diastolic BP (≥135/85 mmHg). Results: In untreated patients (n=200), the prevalence of white-coat hypertension (10.0% vs 17.0%), masked hypertension (26.5% vs 14.5%) significantly (P=0.04) differed between 24 h ambulatory and home BP monitoring. Regardless of the treatment status, compared with 24 h ambulatory BP, home BP measurement had low sensitivity (range 43%-86%) but high specificity (91%-99%), and accordingly low positive predictive values (46%-91%) but high negative predictive values (84%-100%). These two modalities had moderate diagnostic agreement (81%-90%) and Kappa statistic (0.43-0.78). Conclusion: Home BP monitoring has high specificitybut low sensitivity in the diagnosis of white-coat and masked hypertension. It may behave as a complementary to, albeit not a replacement of ambulatory BP monitoring.
[1] | Joint Committee for Guideline Revision. 2018 Chinese Guidelines for Prevention and Treatment of Hypertension-A report of the Revision Committee of Chinese Guidelines for Prevention and Treatment of Hypertension[J]. J Geriatr Cardiol, 2019, 16(3):182-241. |
[2] | O'Brien E1, Parati G, Stergiou G, et al. European Society of Hypertension position paper on ambulatory blood pressure monitoring[J]. J Hypertens, 2013, 31(9):1731-1768. |
[3] | Whelton PK, Carey RM, Aronow WS, et al. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines[J]. Hypertension, 2018, 71(6):e13-e115. |
[4] | Williams B, Mancia G, Spiering W, et al. 2018 ESC/ESH Guidelines for the management of arterial hypertension[J]. Eur Heart J, 2018, 39(33):3021-3104. |
[5] | Mancia G, Facchetti R, Bombelli M, et al. Long-term risk of mortality associated with selective and combined elevation in office, home, and ambulatory blood pressure[J]. Hypertension, 2006, 47(5):846-853. |
[6] | Franklin SS, Thijs L, Hansen TW, et al. Significance of white-coat hypertension in older persons with isolated systolic hypertension: a meta-analysis using the international database on ambulatory blood pressure monito-ring in relation to cardiovascular outcomes population[J]. hypertension, 2012, 59(3):564-571. |
[7] | Parati G, Omboni S, Bilo G. Why is out-of-office blood pressure measurement needed?[J]. Hypertension, 2009, 54(2):181-187. |
[8] | Nasothimiou EG, Tzamouranis D, Rarra V, et al. Diagnosis accuracy of home vs. ambulatory blood pressure monitoring in untreated and treated hypertension[J]. Hypertension Res, 2012, 35(7):750-755. |
[9] | Hänninen MR, Niiranen TJ, Puukka PJ, et al. Comparison of home and ambulatory blood pressure measurement in the diagnosis of masked hypertension[J]. J Hypertens, 2010, 28(4): 709-714. |
[10] | Bayó J, Cos FX, Roca C, et al. Home blood pressure self-monitoring: diagnostic performance in white-coat hypertension[J]. Blood Press Monit, 2006, 11(2): 47-52. |
[11] | Stergiou GS, Salgami EV, Tzamouranis DG, et al. Masked hypertension assessed by ambulatory blood pressure versus home blood pressure monitoring: is it the same phenomenon?[J]. Am J Hypertens, 2005, 18(6):772-778. |
[12] | Parati G, Stergiou GS. Self measured and ambulatory blood pressure in assessing the 'white-coat' phenomen[J]. J Hypertens, 2003, 21(4):677-682. |
[13] | Stergiou GS, Nasothimiou E, Giovas P, et al. Diagnosis of hypertension in children and adolescents based on home versus ambulatory blood pressure monitoring[J]. J Hypertens, 2008, 26(8):1556-1562. |
[14] | Verdecchia P, Angeli F, Mazzotta G, et al. Home blood pressure measurements will not replace 24-hour ambulatory blood pressure monitoring[J]. Hypertension, 2009, 54(2):188-195. |
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