Effects of mindfulness-based stress reduction on mood disorders and sleep in patients with Alzheimer′s disease in the context of COVID-19

doi:10.16150/j.1671-2870.2022.01.010

Abstract

Abstract:

Objective: To investigate the effects of MBSR(mindfulness-based stress reduction)-based mental rehabilitation intervention on mood disorders and sleep status of patients with mild to moderate Alzheimer′s disease (AD) in long-term hospital during closed management of COVID-19 pandemic. Methods: A total of 70 patients with mild to moderate AD who were admitted to hospital before January 2020 were enrolled. All patients received an 8-week psychological rehabilitation intervention based on MBSR from February 11, 2020 to April 30, 2020. Prior to the intervention, general patient data were collected, including Hamilton Anxiety Scale(HAMA), The 15-item Geriatric Depression Scale(GDS-15) and Pittsburgh Sleep Quality Index(PSQI) and other assessment scales were used for initial assessment of each enrolled patient, and re-assessment was performed at the end of the 8-week intervention. After the initial assessment, correlation analysis was conducted between general patient data and the results of the initial assessment in patients. Results: It revealed that anxiety, depression, sleep status of patients were negatively correlated with their education level (R<-0.4; P≤0.01); the sleep status score of patients was positively correlated with the degree of anxiety and depression (R>0.4; P≤0.01); GDS, HAMA and PSQI scores of the patients were significantly improved after 8 weeks of intervention compared with the initial evaluation(P<0.05). Conclusions: Mental rehabilitation intervention based on MBSR during closed management due to COVID-19 can improve anxiety, depression and other mood disorders and sleep status of patients with long-term inpatient mild to moderate AD.

Key words: Mindfulness-based stress reduction, Mild to moderate Alzheimer′s disease, Mood disorders, Sleep

CLC Number:

R541.7

FU Conghui, XU Ying, SU Wei, WEN Jing, LIU Zhifang, ZHU Qian, ZHANG Jingyi, XIONG Zemin, CHEN Lanlan, JIA Jie. Effects of mindfulness-based stress reduction on mood disorders and sleep in patients with Alzheimer′s disease in the context of COVID-19[J]. Journal of Diagnostics Concepts & Practice, 2022, 21(01): 46-51.

Figures/Tables 5

References 36

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项目	特征	统计值
年龄（岁）^a）		82.0（75,87）
性别（男/女）（%）	男	27（39.7）
	女	41（60.3）
受教育程度（年）	文盲	12（17.6）
	小学	16（23.5）
	初中	16（23.5）
	高中	12（17.6）
	大学及以上	12（17.6）
MMSE评分（分）^a）		15.5（14,19）
ADL评分（分）^a）		55.0（40.0,78.8）
婚姻状况（%）	健在	26（38.2）
	离异/丧偶	42（61.8）
吸烟（%）	有	15（22.1）
	无	53（77.9）
高血压（%）	有	30（44.1）
	无	38（55.9）
糖尿病（%）	有	21（30.9）
	无	47（69.1）
听力障碍（%）	有	25（36.8）
	无	43（63.2）

变量	r值
变量	HAMA	GDS-15	PSQI
受教育程度	-0.497	-0.487	-0.416

变量	r值
变量	HAMA	GDS-15
PSQI	0.460^*	0.484

分组	HAMA	GDS	PSQI
干预前	8（5,11）	8（5,9）	10（7,13）
干预后	5（4,8）	6（4,7.75）	8（6,10.75）
Z值	-3.243	-3.051	-2.464
P值	0.001	0.002	0.014