Phenotypes of chronic obstructive pulmonary disease with preserved ratio impaired spirometry (PRISm)

doi:10.16150/j.1671-2870.2023.03.05

Abstract

Abstract:

The Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2023 first proposed “Preserved Ratio Impaired Spirometry (PRISm)”, which is the ratio of post-bronchodilator forced expiratory volume in one second to forced vital capacity is normal (FEV1/FVC ≥ 0.7) as pulmonary ventilation function is impaired (post-bronchodilator FEV1% and/ or FVC%<80%. It is particularly necessary to pay attention to the PRISm population with significant FVC deterioration. PRISm was associated with increased incidence of complications and all-cause mortality in the patients with in chronic obstructive pulmonary disease (COPD). In GOLD 2023, it was clarified that PRISm patients should be considered as COPD patients for early screening, standardized treatment, due to their significant clinical symptoms, lung function deterioration, and or abnormal bronchoalveolar structure even if their airway limitation does not meet the criteria for COPD. The cohort studies for large sample, multi-center, long-term follow-up with PRISm in China should be investigated in future.

Key words: Preserved ratio impaired, Chronic obstructive pulmonary disease, Disease management, Global initiative

CLC Number:

R563

SUN Xianwen, LI Qingyun. Phenotypes of chronic obstructive pulmonary disease with preserved ratio impaired spirometry (PRISm)[J]. Journal of Diagnostics Concepts & Practice, 2023, 22(03): 234-237.

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