Original articles

Comparative analysis of 2005 and 2017 version of diagnostic criteria for dementia with Lewy bodies

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  • 1. Department of Gerontology, First People’s Hospital of Lianyungang, Jiangsu Province, Jiangsu Lianyungang 222000, China;;
    2. Department of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

Received date: 2018-06-13

  Online published: 2018-08-25

Abstract

Objective: To understand and study the diagnostic criteria, treatment and prognosis of 2017 version of guideline for dementia with Lewy bodies (DLB) to elevate the understanding and recognition of DLB for having more patients to be diagnosed at early stage to receive whole-course management and comprehensive treatment. Methods: The clinical characteristics and treatment of 30 patients who met the 2005 version of diagnostic criteria for DLB were retrospectively analyzed and were diagnosed again using the 2017 version of diagnostic criteria for DLB. Results: According to the 2017 version of diagnostic criteria for DLB, 27 cases were diagnosed as probable DLB, 3 cases were diagnosed as possible DLB. There were 29 cases(96.7%) with Parkinson's syndrome, 16 cases(53.3%) with fluctuating cognitive impairment, 25 cases (83.3%) with visual hallucinations, 11 cases(36.7%) with REM sleep behavior disorder. There were 21 cases (70%) initiated with Parkinson's syndrome and 9 cases(30%)initiated with cognitive impairment and visual hallucinations. Conclusions: The 2017 version of diagnostic criteria for DLB increases the weight of REM sleep behavior disorder(polysomnographic abnormality) and abnormal 123iodine-MIBG myocardial scintigraphy, providing objective basis for the early recognition and diagnosis of DLB, and is beneficial for patients to receive early management and comprehensive treatment, thereby improving the prognosis of the disease.

Cite this article

MENG Jie, CUI Shishuang, MENG Yunxia, WANG Gang . Comparative analysis of 2005 and 2017 version of diagnostic criteria for dementia with Lewy bodies[J]. Journal of Diagnostics Concepts & Practice, 2018 , 17(04) : 414 -418 . DOI: 10.16150/j.1671-2870.2018.04.011

References

[1] McKeith IG, Dickson DW, Lowe J, et al. Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium[J]. Neurology,2005,65(12):1863-1872.
[2] McKeith IG, Boeve BF, Dickson DW, et al. Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium[J]. Neurology,2017,89(1):88-100.
[3] Hogan DB, Fiest KM, Roberts JI, et al. The Prevalence and Incidence of Dementia with Lewy Bodies: a Systema-tic Review[J]. Can J Neurol Sci,2016,43 Suppl 1:S83-S95.
[4] Jellinger KA.Dementia with Lewy bodies and Parkinson's disease-dementia: current concepts and controversies[J]. J Neural Transm(Vienna),2018,125(4):615-650.
[5] Haider A, Dulebohn SC.Dementia, Lewy body[M]. Treasure Island (FL): StatPearls Publishing,2018.
[6] Kim WS, Kågedal K, Halliday GM.Alpha-synuclein biology in Lewy body diseases[J]. Alzheimers Res Ther,2014, 6(5):73.
[7] Ferman TJ, Boeve BF, Smith GE, et al.Inclusion of RBD improves the diagnostic classification of dementia with Lewy bodies[J]. Neurology,2011,77(9):875-882.
[8] Connors MH, Quinto L, McKeith I, et al. Non-pharmacological interventions for Lewy body dementia: a systema-tic review[J]. Psychol Med,2018,48(11):1749-1758.
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