Objective: To study the distribution of pathogenic bacteria and drug resistance in neonatal bloodstream infection for providing a reference for the rational use of antimicrobialagents. Methods: The distribution of pathogenic bacterial strains isolated from blood culture specimens of neonates and its drug resistance at Shanghai First Maternity and Infant Hospital from 2014 to 2017 were analyzed retrospectively. Results: A total of 500 1 blood specimens collected from in-patient neonates from 2014-2017 were cultured.Among them, 153 cases of neonatal bloodstream infection were detected and 155 strains of bacteria were isolated. Of these strains there were 88 strains of Gram-positive bacteria,mainly composed of 38 strains of coagulase-negative Staphylococci (CNS), 20 strains of S.agalactiae, 18 strains of Staphylococcus aureus; 57 strains were Gram-negative bacteria strains, mainly composed of 18 strains of Escherichia coli,17 strains of Klebsiella pneumoniae; and 10 strains were fungi. Of these cases 54 were neonatal early-onset blood stream infection, the main pathogens were S.agalactiae (27.27%) and E. coli(21.82%); 99 cases were neonatal late-onset blood stream infection, the main pathogens were coagulase-negative Staphylococcus (25.00%), Staphylococcus aureus(17%) and K. pneumoniae (15%). Thirty eight of the 56 Staphylococci strains were identified as methicillin-resistant Staphylococcus. S.agalactiae had higher resistance to clindamycin, erythromycin and tetracycline, the resistance rates were 95.00%, 85.00 and 95.00%, respectively. E. coli and K. pneumoniae had higher resistance to ampicillin, piperacillin, and cephalosporin, the resistance rates were 88.57%, 62.86%, 62.86%, respectively, the detection rate of ESBLs-producing strains was 60%. Conclusions: S.agalactiae and E. coli are the main pathogens of neonatal early-onset bloodstream infection, while coagulase negative stapylococci, Staphylococcus aureus and K. pneumoniae are the main pathogens of neonatal late-onset bloodstream infection. Higher drug resistance is found in pathogens of neonatal late-onset bloodstream infection.
SHEN Xiaohong, CHEN Huifen, ZHANG Jun, YE Jianbo, ZHANG Xianhua
. Distribution of pathogenic bacteria in neonatal bloodstream infection and analysis of drug resistance during 2014 to 2017[J]. Journal of Diagnostics Concepts & Practice, 2018
, 17(03)
: 266
-271
.
DOI: 10.16150/j.1671-2870.2018.03.007
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