Original articles

Value of P-wave dispersion, NT-proBNP for prediction of recurrence of atrial fibrillation following cryoballoon ablation

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  • Department of Cardiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

Received date: 2019-07-16

  Online published: 2020-02-25

Abstract

Objective: To investigate the predictive value of P-wave dispersion and N-terminal pro-brain natriuretic peptide (NT-proBNP) for recurrence of atrial fibrillation (AF) after successful cryoballoon ablation. Methods: A total of 182 patients with paroxysmal AF with successful cryoballoon ablation were enrolled. A 12-lead electrocardiogram (EKG) was used to record the P-wave for calculating P-wave dispersion before ablation and 1 day, 1 month, 3 months and 6 months after ablation, and plasma NT-proBNP was measured at the same time. A 6-month follow-up was carried out for studying the recurrence of AF, and the clinical, EKG and ablation data were analyzed. Results: The recurrence rate of AF within 6 months after successful cryoballoon ablation was 21.4%. Compared with patients with AF recurrence, those without AF recurrence were younger in age [(47.6±6.1) years vs. (60.2±9.5) years], having higher percentage of lone AF(69.5% vs. 47.3%) and smaller P-wave dispersion. P-wave dispersions were decreased at 3, 6 months after ablation in patients without AF recurrence, while in patients with AF recurrence no significant changes were found. Level of NT-proBNP in patients without AF recurrence were lower than those in patients with AF recurrence. Level of NT-proBNP was decreased after ablation in patients without AF recurrence, while no significant change was found in patients with AF recurrence. Meanwhile patients remained free from AF for 6 months had smaller left atrial diameter(LAD) before ablation than those with recurrence of AF[(41.3±2.7) mm vs.( 46.6±4.4) mm], and LAD was further decreased at 6 months [from(41.3±2.7) mm to (38.0±2.0) mm] (P<0.05). Multivariate regression analysis showed that LAD (OR: 1.3, 95% CI: 0.9-1.0, P<0.05), P-wave dispersion (OR: 1.2, 95% CI: 1.0-1.1, P=0.04) and NT-proBNP level(OR: 2.3, 95%CI: 1.3-1.7, P=0.03) before ablation were independent predictors of AF recurrence after ablation. Conclusions: P-wave dispersion and NT-proBNP level may provide reference information for prediction of recurrence of AF after cryoballon ablation.

Cite this article

LUO Xiaoying, XU Yan, ZHANG Fengru, WU Liqun, QI Wenhang . Value of P-wave dispersion, NT-proBNP for prediction of recurrence of atrial fibrillation following cryoballoon ablation[J]. Journal of Diagnostics Concepts & Practice, 2020 , 19(1) : 32 -36 . DOI: 10.16150/j.1671-2870.2020.01.008

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