Objective: To explore the value of pre-operative CT scanning for preoperative, intraoperative, and postope-rative evaluation of patients with pheochromocytoma. Methods: A total of 164 patients with pheochromocytoma were enrolled from January 2014 through April 2019. Correlation of pre-operative CT imaging parameters product of enhanced CT value in the lesion and tumor size (EV) with levels of preoperative metanephrine (MN) and normetanephrine (NMN), loss of intraoperative blood, postoperative complications were analyzed. Results: Both pre-operative NMN and MN were positively correlated with EV (P<0.001, P=0.001). Multivariate analysis showed that NMN was an independent factor for increment of EV(P=0.001). EV had a significant positive correlation with intraoperative dosage of phentolamine (P<0.001) and blood loss (P<0.001). Receiver operator characteristic (ROC) curve analysis showed that when EV was greater than 4 719.65 HU·cm³ (P<0.001, AUC=0.890), the risk of major intraoperative blood, defined as loss >800 mL, increased significantly. EV was positively correlated with incidence of postoperative complications (P<0.001). When EV was greater than 15 610.62 HU·cm³ (P<0.001, AUC=0.799), the risk of postoperative complications >Ⅱ significantly increased. Conclusions: CT-based imaging parameter EV is highly correlated with intraoperative phentolamine dosage, incidence of postoperative complications and levels of pre-operative NM, NMN. Pre-operative CT scanning might provide important information for preoperative preparation, intraoperative anesthesia and prevention of postoperative complications in the manangement of pheochromocytoma.