Objective: To evaluate the effect of different endometrial preparation on outcome of in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) frozen-thawed embryo plantation in patients with history of ectopic pregnancy. Methods: Data from 914 patients with history of ectopic pregnancy who underwent IVF/ICSI frozen-thawed embryo plantation from January 2012 to December 2014 were collected. Patients undergoing natural cycles and those undergoing artificial cycles were matched into 379 pairs by propensity score matching. Pregnancy outcomes were compared between the two matched groups of patients. Results: The basic characteristics including maternal age, body mass index, full-term birth history, primary or secondary infertility, previous tubal surgery history, infertility diagnosis, endometrial thickness on embryo plantation day, number and stage of embryos planted, and year of treatment were not significantly different between the two groups (P>; 0.05). As for pregnancy outcome, the ectopic pregnancy rate of the two groups was not significantly different (5.2% vs.7.5%, P>; 0.05). Moreover, biochemical pregnancy rate, clinical pregnancy rate, delivery rate, miscarriage rate, and multiple pregnancy rate of the two groups were also not significantly different (P>; 0.05). Conclusions: In IVF/ICSI frozen-thawed embryo plantation, natural cycles and artificial cycles have similar effect on recurrence risk of ectopic pregnancy, and have comparable pregnancy outcome.
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