Original articles

The relationship between plasma total testosterone and osteocalcin levels in males with newly diagnosed type 2 diabetes

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  • Department of Endocrinology, People’s Hospital of Shanghai Putuo, Tongji University, Shanghai 200060, China

Received date: 2021-02-02

  Online published: 2021-12-25

Abstract

Objective: To explore the relationship between plasma total testosterone and osteocalcin levels in males with newly diagnosed type 2 diabetes. Methods: A total of 146 males with newly diagnosed type 2 diabetes mellitus admitted from January 2018 through June 2020 were enrolled in the study. The patients were divided into four groups according to the level of osteocalcin: Q1 group (<8.0 nmol/L), Q2 group (8.0-<10.9) nmol/L, Q3 group (10.9-<14.7 nmol/L) and Q4 group (≥14.7 nmol/L). The parameters of glucose and lipid metabolism and total testosterone levels were compared among groups and multiple linear regression was adopted to analyze the relationship of osteocalcin, total testosterone and other indexes. Results: It revealed that 58 (39.72%) patients also had hypogonadism, with the level of osteocalcin decreased to (11.27±5.62) nmol/L, significantly lower than patients with normal gonadal function(13.22±5.83 nmol/L)(P<0.05). The total testosterone level in males with newly diagnosed type 2 diabetes increased along with osteocalcin (P<0.05). Pearson correlation analysis showed that osteocalcin was positively correlated with total testosterone, serum creatinine and serum calcium (P<0.05). Partial correlation analysis showed that after adjusting for age, body mass index (BMI), smoking, drinking, serum creatinine, blood calcium, total cholesterol, triglyceride, fasting insulin (FINS), glycosylated hemoglobin (HbA1c) and insulin resistance index(HOMR-IR), the level of osteocalcin was still positively correlated with total testosterone(P<0.01). Patients with higher osteocalcin had higher levels of total testosterone and blood calcium(Q4 Group), but lower BMI, HOMR-IR, fasting blood glucose and HbA1c. Multiple stepwise regression analysis revealed that high osteocalcin was an independent factor for elevated level of total testosterone (β value 0.197, P<0.05). Conclusions: Plasma total testosterone level is positively correlated with osteocalcin in newly diagnosed male patients with type 2 diabetes mellitus.

Cite this article

WANG Guangyu, YANG Xin, ZHANG Lijuan, TAN Jiaorong . The relationship between plasma total testosterone and osteocalcin levels in males with newly diagnosed type 2 diabetes[J]. Journal of Diagnostics Concepts & Practice, 2021 , 20(06) : 573 -578 . DOI: 10.16150/j.1671-2870.2021.06.011

References

[1] Morton A. Frequent occurrence of hypogonadotropic hypogonadism in type 2 diabetes[J]. J Clin Endocrinol Metab, 2005, 90(3):1903.
[2] Sepu N, Adeleye JO, Kuti MO. Serum testosterone in Nigerian men with type 2 diabetes mellitus and its relationship with insulin sensitivity and glycemic control[J]. J Natl Med Assoc, 2021, 113(3):285-293.
[3] Farooq R, Bhat MH, Majid S, et al. Association between T2DM and the lowering of testosterone levels among Kashmiri males[J]. Arch Endocrinol Metab, 2021, 64(5):528-532.
[4] Grossmann M. Testosterone and glucose metabolism in men: current concepts and controversies[J]. J Endocrinol, 2014, 220(3):R37-R55.
[5] Hamahara J, Honda H, Yamamoto K, et al. Clinical characteristics of low androgen status in males with type 2 diabetes mellitus[J]. Acta Med Okayama, 2021, 75(1):1-8.
[6] Kunutsor SK, Apekey TA, Laukkanen JA. Association of serum total osteocalcin with type 2 diabetes and intermediate metabolic phenotypes: systematic review and meta-analysis of observational evidence[J]. Eur J Epidemiol, 2015, 30(8):599-614.
[7] Moser SC, van der Eerden BCJ. Osteocalcin-a versatile bone-derived hormone[J]. Front Endocrinol (Lausanne), 2019, 9:794.
[8] Turcotte AF, Grenier-Larouche T, Lacombe J, et al. Association between changes in bioactive osteocalcin and glucose homeostasis after biliopancreatic diversion[J]. Endocrine, 2020, 69(3):526-535.
[9] Saucedo R, Rico G, Vega G, et al. Osteocalcin, under-carboxylated osteocalcin and osteopontin are not associa-ted with gestational diabetes mellitus but are inversely associated with leptin in non-diabetic women[J]. J Endocrinol Invest, 2015, 38(5):519-526.
[10] Jürimäe J, Lätt E, Mäestu J, et al. Osteocalcin is inversely associated with adiposity and leptin in adolescent boys[J]. J Pediatr Endocrinol Metab, 2015, 28(5-6):571-577.
[11] Deng H, Lu H, Dai Y, et al. Relationship between serum osteocalcin and carotid atherosclerosis in middle-aged men in China: a cross-sectional study[J]. Biomed Res Int, 2018, 2018:1751905.
[12] 田骆冰, 房辉, 徐刚, 等. 中年男性2型糖尿病伴血脂异常患者骨钙素与股动脉内膜中层厚度及下肢动脉斑块的关系[J]. 中华糖尿病杂志, 2020, 12(6):398-403.
[13] Lee NK, Karsenty G. Reciprocal regulation of bone and energy metabolism[J]. Trends Endocrinol Metab, 2008, 19(5):161-166.
[14] Zhang XL, Wang YN, Ma LY, et al. Uncarboxylated osteocalcin ameliorates hepatic glucose and lipid metabolism in KKAy mice via activating insulin signaling pathway[J]. Acta Pharmacol Sin, 2020, 41(3):383-393.
[15] Oury F, Sumara G, Sumara O, et al. Endocrine regulation of male fertility by the skeleton[J]. Cell, 2011, 144(5):796-809.
[16] Lombardi G, Perego S, Luzi L, et al. A four-season molecule: osteocalcin. Updates in its physiological roles[J]. Endocrine, 2015, 48(2):394-404.
[17] Feldman HA, Longcope C, Derby CA, et al. Age trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal results from the Massachusetts male aging study[J]. J Clin Endocrinol Metab, 2002, 87(2):589-598.
[18] Lu Y, Li J, Cheng X, et al. Testosterone level in aging male with different glucose tolerance state and its association with osteocalcin[J]. Aging Male, 2019, 22(1):68-73.
[19] Abdul Sultan A, Mallen C, Hayward R, et al. Gout and subsequent erectile dysfunction: a population-based cohort study from England[J]. Arthritis Res Ther, 2017, 19(1):123.
[20] Lee CH, Olson P, Evans RM. Minireview: lipid metabolism, metabolic diseases, and peroxisome prolifera-tor-activated receptors[J]. Endocrinology, 2003, 144(6):2201-2207.
[21] Oury F, Ferron M, Huizhen W, et al. Osteocalcin regulates murine and human fertility through a pancreas-bone-testis axis[J]. J Clin Invest, 2013, 123(6):2421-2433.
[22] Dallas SL, Prideaux M, Bonewald LF. The osteocyte: an endocrine cell... and more[J]. Endocr Rev, 2013, 34(5):658-690.
[23] Sun L, Kanwar YS. Relevance of TNF-α in the context of other inflammatory cytokines in the progression of diabetic nephropathy[J]. Kidney Int, 2015, 88(4):662-665.
[24] Kelly DM, Jones TH. Testosterone and obesity[J]. Obes Rev, 2015, 16(7):581-606.
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