Objective: To explore the correlation between nutritional risk and exercise tolerance in patients with idiopathic pulmonary hypertension (IPAH）. Methods: Nutritional risk was assessed in 96 IPAH patients according to the nutritional risk screening 2002 (NRS-2002). Based on the results of the assessment, they were divided into with nutritional risk group (group A, n=46) and without nutritional risk group (group B, n=50). Arterial blood gas analysis (ABG) was performed in the two groups. The pulmonary function test (PFT) and cardiopulmonary exercise test (CPET) were performed, respectively. Results: ① There were no significant differences in height and age between two groups (P>0.05). The weight and BMI in group A were lower than those in group B. There were no significant differences in blood gas parameters PaO2 and PaCO2 between two groups (P>0.05). ② Pulmonary function tests showed that the FVC, FEV1 in group A were significantly lower than those in group B (P<0.05). The FVC%pred, FEV1%pred, DLCO, DLCO%pred in group A were significantly lower than that in group B (P<0.01). There were no significant differences in other indices (FEV1/FVC, IC, TLC, RV, RV/TLC) between two groups (P>0.05). ③ In cardiopulmonary exercise test, peak VO2%pred, peak load, peak VO2, peak VO2/kg, peak VE in group A were significantly lower than those in group B (P<0.05 or P<0.01). There were no significant differences in peak O2 pulse between the two groups (P>0.05). Of the 96 IPAH patients, the NRS score showed a significant negative correlation with peak VO2 and peak load (r=-0.342 and -0.335, P<0.01), and showed a negative correlation with peak VO2/kg (r=-0.213, P<0.05). Conclusions: The nutritional risk of patients with IPAH can worsen pulmonary ventilation function and diffusion, and decrease exercise tolerance significantly. Nutritional risk assessment may help to understand the severity of patients with IPAH and predict the clinical risk.
DONG Fang, ZHANG Yihui, GUO Jian, LIU Jinming
. Correlation between nutritional risk and exercise tolerance in patients with idiopathic pulmonary arterial hypertension[J]. Journal of Diagnostics Concepts & Practice, 2018
, 17(06)
: 664
-669
.
DOI: 10.16150/j.1671-2870.2018.06.008
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