Original article

Distribution and drug resistance of pathogens in urinary tract infections in Zhoupu area, Shanghai during 2016 to 2020

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  • Dpartment of Clinical Laboratory, Zhoupu Hospital, Shanghai University of Medicine and Health Science, Shanghai Pudong New District, Shanghai 201318, China

Received date: 2021-01-22

  Online published: 2022-06-28

Abstract

Objective: To study the distribution and drug resistance of pathogens in urinary tract infections(UTI), and to provide evidence for rational treatment of the disease. Methods: The results of bacterial culture from morning clean-catch mid-streamurinein the patients with UIT during July 2016 to June 2020 were retrospectively analyzed to determine the distribution and drug resistance of pathogens. Result A total of 3 543 specimens were collected, 810 strains of pathogens were isolated, and the positive rate was 22.9%, including 558 strains of Gram-negative bacteria (68.9%), 113 strains of Gram-positive cocci (14.0%), 128 strains of Mycoplasma(15.8%), 11 strains of fungi(1.4%). The majority of bacteria strains were Escherichia coli (337 strains, 41.6%) and Klebsiella pneumoniae (67 strains, 8.3%). Ureaplasma urealyticum(UU) accounted for 10.6% (86 strains) inisolated mycoplasma. Escherichia coli and Proteusisolates were sensitive to aminoglycoside and carbapenem antibiotics and the resistant rates were lower than 5%; Klebsiella pneumoniae was resistant to ceftriaxone and levofloxacin and its′ resistant rates were 58.3% and 55.2%, respectively.All Enterococci strains were resistant to penicillin, ampicillin, gentamicin, and levofloxacin, which had higher resistance rates than those in Enterococcus faecalis; Enterococcus faecalis had high resistant rates to levofloxacin and moxifloxacin(73.3% and 64.4%, respectively). Staphylococcus aureus and Enterococcus were sensitive to sulfonamides, glycopeptides and common broad-spectrum antibiotics, and the resistant rates were lower than 5%. The drug resistant rate of UU to ciprofloxacin was 69.9%, and UU was sensitive to both minocycline and doxycycline. Conclusions: The majority of pathogens isolated from UTI patients in Zhoupu District of Shanghai is Gram-negative bacilli, which shows different degree of resistance to common antibiotics. Therefore, the regular monitoring of UTI pathogenic bacteria is important to determine how to choose antibiotics in clinical practice.

Cite this article

KONG Nana, ZHANG Peiyan, YANG Deping, JIN Huimin, ZHENG Jianghua . Distribution and drug resistance of pathogens in urinary tract infections in Zhoupu area, Shanghai during 2016 to 2020[J]. Journal of Diagnostics Concepts & Practice, 2021 , 20(01) : 93 -97 . DOI: 10.16150/j.1671-2870.2021.01.015

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