Journal of Diagnostics Concepts & Practice >

2016 , Vol. 15 >Issue 05: 492 - 497

DOI: https://doi.org/10.16150/j.1671-2870.2016.05.012

Original articles

New silent cerebral infarction in patients with hypertensive intracerebral hemorrhage: related risk factors and prognosis

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  • 1. Department of Neurology & Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China;
    2. Department of Neurology,Minhang Hospital, Fudan University, Shanghai 201100, China

Received date: 2016-06-10

  Online published: 2022-07-27

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Abstract

Objective: To investigate the frequency and risk factors of new silent brain infarction (SBI) in patients with acute hypertensive intracerebral hemorrhage(ICH) and to analyze the association of new SBI with subsequent clinical cerebrovascular events and vascular related deaths. Methods: This prospective study was performed on 100 patients diagnosed as hypertensive ICH within 3 days after onset and MRI was performed on the fifth day after onset to detect new SBI and lesions of cerebral microbleeds(CMBs). Patients were regularly followed up one year for subsequent clinical cerebrovascular events and vascular related death. Results: Fourteen new SBI were observed in 11(11%) patients. Univariate analysis showed that baseline cerebral microbleeds (CMBs) and white matter leukoaraiosis were associated with new SBI. During 1 year of follow-up, 14 patients experienced clinical cerebrovascular events or vascular related deaths, including 9 cases of cerebral infarction, 1 case of recurrent cerebral hemorrhage and 4 cases of vascular related death. Cox proportional hazards models showed that age, atrial fibrillation and new SBI were independently associated with clinical cerebrovascular events or vascular related death. Conclusions: New SBI frequently occurs during the acute phase of ICH and is mainly associated with CMBs and white matter leukoaraiosis. The risk of subsequent clinical cerebrovascular events and vascular related death is increased in hypertensive ICH patients with new SBI.

Key words： Silent brain infarction; Hypertensive intracerebral hemorrhage; Cerebral small vessel diseases; Magnetic resonance imaging

Cite this article

MU Jinjin, YANG Kang, FENG Yulan, FU Yi . New silent cerebral infarction in patients with hypertensive intracerebral hemorrhage: related risk factors and prognosis[J]. Journal of Diagnostics Concepts & Practice, 2016 , 15(05) : 492 -497 . DOI: 10.16150/j.1671-2870.2016.05.012

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