Objective: To investigate the risk factors for delayed healing of peptic ulcer in patients with upper gastrointestinal bleeding (UGIB), so as to provide evidences for clinical treatment. Methods: A total of consecutive 138 hospitalized patients with UGIB due to peptic ulcer from January 2012 to December 2021 were enrolled. The healing rate of peptic ulcer was determined under reexamination of gastroscopy after 1 week of treatment. The related indice were analyze with univariate analysis to determine possible influencing factors for peptic ulcer, including gender, age, body mass index (BMI), diabetes, history of taking steroid anti-inflammatory drugs (NSAIDS), smoking, drinking, Helicobacter pylori (Hp) infection, hemoglobin, serum albumin, ulcer location or Logistic regression analysis was performed to determine the independent risk factors. Results: Univariate analysis showed that age, levels of serum albumin, Forrest classification, the location and size of ulcers were associated with delayed healing of ulcers in patients with upper gastrointestinal bleeding (P<0.05). Multivariate Logistic regression analysis showed that Forrest classification, location and size of ulcers were independent risk factors for delayed healing of ulcers in patients with upper gastrointestinal bleeding(P<0.05). Conclusions: Forrest classification, location and size of ulcers in patients with upper gastrointestinal bleeding may delay the healing of peptic ulcer in patients with upper gastrointestinal bleeding and countermeasures should be taken to deal with the above risk factors.