Journal of Diagnostics Concepts & Practice >

2022 , Vol. 21 >Issue 05: 613 - 618

DOI: https://doi.org/10.16150/j.1671-2870.2022.05.011

Original articles

Clinical analysis of changes of ambulatory blood pressure in children with primary nephrotic syndrome

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  • 1a. Department of Nephrology, 1b. International Medical Department, 1c. Neonatal Intensive Care Unit, Shanghai Children′s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China
    2. Department of Pediatrics, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Liaoning Shenyang 110032, China

Received date: 2022-02-07

  Online published: 2023-01-29

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Abstract

Objective: To explore the characteristics of the changes of ambulatory blood pressure (ABP) in the children with primary nephrotic syndrome (PNS). Methods: A total of 106 PNS children′s reports of 24-hour ambulatory blood pressure in Shanghai Children′s Medical Center were analyzed retrospectively. Results: The incidence of hypertension in PNS children was 60.4% (64/106), and 58.5% (62/106) children had nighttime hypertension, and 16.0% (17/106） children had daytime hypertension. The incidence of hypertension at night was higher than that in daytime(P<0.05). The loads of systolic blood pressure (SBP) and diastolic blood pressure (DBP) at night were higher than those at the daytime (SBP 52.32%±36.87% vs 19.41%±19.70%, DBP 39.22%±34.69% vs 18.42%±21.66%, P<0.05). Among 106 children, 92(86.8%) had abnormal circadian rhythms in SBP and/or DBP ambulatory blood pressure, and most of them were non-dippers (68.9%). SBP rhythm was more likely to be abnormal than DBP rhythm (79.2% vs 65.1%, P=0.022). There was a statistical difference in the rate of blood pressure decline between SBP and DBP at night [SBP (3.52%±6.97%) vs DBP (7.78%±9.18%), P<0.001]. The incidence of white-coat hypertension was 12.3%, and the incidence of masked hypertension was 14.2%. Conclusions: PNS children are prone to nocturnal hypertension and abnormal circadian rhythm, especially SBP. 24 h ambulatory blood pressure is conducive to collecting blood pressure change information and to guide the rational use of antihypertensive drugs for PNS children.

Key words： Ambulatory blood pressure; Pediatric; Primary nephrotic syndrome

Cite this article

SHEN Xiaoyu, SHA Sha, YIN Lei, ZHOU Wei, LUO Ningxin, WANG Xuefeng . Clinical analysis of changes of ambulatory blood pressure in children with primary nephrotic syndrome[J]. Journal of Diagnostics Concepts & Practice, 2022 , 21(05) : 613 -618 . DOI: 10.16150/j.1671-2870.2022.05.011

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