Journal of Diagnostics Concepts & Practice >

2023 , Vol. 22 >Issue 04: 374 - 378

DOI: https://doi.org/10.16150/j.1671-2870.2023.04.007

Original articles

Establishment and verification of reference range of parameters related to uterine artery measured by ultrasound at 11~40 weeks of pregnancy

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  • Department of Ultrasound, the International Peace Maternity and Child Health Hospital,School of Medicine,Shanghai Jiao Tong University; Shanghai Key Laboratory of Embryo Original Diseases; Institute of Birth Defects and Rare Diseases,School of Medicine,Shanghai Jiao Tong University,Shanghai 200030, China

Received date: 2023-02-15

  Online published: 2023-12-18

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Abstract

Objective: To establish and verify the normal reference range of uterine artery mean pulsatility index (mPI) between 11-40 weeks of pregnancy in low-risk population. Methods: Pregnant women registered in our hospital from January 2019 to July 2023 and underwent ultrasound examination at 11 to 40 weeks were enrolled. By Ultrasound diagnosis, the pulsatility index (PI) of bilateral uterine arteries were measured, and whether there was a notch in the early diastolic period was checked. Following up the pregnancy, basic clinical data and fetal birth information were collected. Results: A total of 1365 low-risk people with normal pregnancy outcomes were included. The 104 cases of adverse pregnancy outcomes were wed to verify the refernce range, including pregnancy included hypertension (n=41) and fetalgrowth restriction (n=23). With the increase of gestation age, mPI showed a gradual downward trend. There was a rapid decline before 20 weeks of gestation (mPI 95th percentile at 11 weeks and 20 weeks of gestation were 2.35 and 1.54, respectively), then declined slowly, and mPI stabilized after 32 weeks of gestation (95th percentile mPI at 32 weeks and 39 weeks of gestation were 0.91 and 0.87, respectively). With the increase of gestation age, the detection rate of early diastolic notch in bilateral uterine arteries decreased gradually. The detection rate was 69.20% at 11-15 weeks of gestation, 27.01% at 21-25 weeks of gestation, then stabilized and decreased to 6.31% at 36-40 weeks of gestation. The results of receiver operating characteristic (ROC) curve analysis showed that the sensitivity and specificity of mPI ≥95th precentile in predicting hypertensive disorder complicating pregnancy were 30.11% and 93.21%, respectively; The sensitivity and specificity in predicting fetal growth restriction were 61.9% and 92.85%, respectively. Conclusions: Establishing the reference range of uterine artery mPI at 11-40 weeks of pregnancy in low-risk population may be used for prospective exclusion of gestational hypertension and fetal growth restriction.

Key words： Ultrasound; Uterine artery; Doppler; Pulsatility index

Cite this article

GONG Xiaoping, CAO Yunyun, WANG Haifei, WANG Guanjie, ZENG Min . Establishment and verification of reference range of parameters related to uterine artery measured by ultrasound at 11~40 weeks of pregnancy[J]. Journal of Diagnostics Concepts & Practice, 2023 , 22(04) : 374 -378 . DOI: 10.16150/j.1671-2870.2023.04.007

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