Original articles

Value of 18F-fluorodeoxyglucose positron emission tomography/magnetic resonance imaging (18F-FDG PET/MRI) in diagnosis of postoperative recurrence of pancreatic cancer

  • FENG Guowei ,
  • HUANG Xinyun ,
  • MENG Hongping ,
  • JIANG Xufeng ,
  • CHEN Kemin ,
  • LIN Xiaozhu
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  • Department of Nuclear Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; b. Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

Received date: 2024-06-08

  Accepted date: 2024-10-08

  Online published: 2025-02-25

Abstract

Objective To evaluate the value of 18F-fluorodeoxyglucose positron emission tomography/magnetic resonance imaging (18F-FDG PET/MRI) in the diagnosis of postoperative recurrence of pancreatic cancer. Methods The study included 86 consecutive patients after resection of pancreatic cancer from April 2018 to December 2023, who underwent 18F-FDG PET/MRI from August to September 2024. The efficacy of 118F-FDG PET/MRI in detecting postoperative recurrence of pancreatic cancer was retrospectively analyzed, and compared with that of serum carbohydrate antigen 19-9 (CA19-9) concentration in the diagnosis of recurrence. Results Follow-up confirmed that 67.4% (58/86) of patients experienced recurrence. The primary tumor diameter in the recurrence group (3.4±1.3cm) was larger than in the non-recurrence group (2.7±1.2cm). Among the patients with recurrence, 87.9% (51/58) had systemic recurrence, with the most common sites being liver metastasis and peritoneal metastasis. PET/MRI results changed the treatment plans for 30.2% (26/86) of patients. Among the 86 cases, 79 patients underwent both PET/MRI and serum CA19-9 tests. PET/MRI showed higher diagnostic efficacy for detecting postoperative recurrence of pancreatic cancer compared to serum CA19-9 (AUC: 0.847 vs. 0.719 ). PET/MRI detected 9/12 cases of pancreatic cancer recurrence with normal serum CA19-9 levels, and excluded 5/8 patients with elevated serum CA19-9 levels who did not experience recurrence. Conclusions PET/MRI has great clinical value in the diagnosis of postoperative recurrence of pancreatic cancer. It is particularly meaningful for patients with normal serum CA19-9 level. It can not only diagnose recurrence but also provide the specific site of tumor recurrence and comprehensive information for the formulation of the next treatment plan.

Cite this article

FENG Guowei , HUANG Xinyun , MENG Hongping , JIANG Xufeng , CHEN Kemin , LIN Xiaozhu . Value of 18F-fluorodeoxyglucose positron emission tomography/magnetic resonance imaging (18F-FDG PET/MRI) in diagnosis of postoperative recurrence of pancreatic cancer[J]. Journal of Diagnostics Concepts & Practice, 2024 , 23(05) : 517 -523 . DOI: 10.16150/j.1671-2870.2024.05.008

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