瘦素与重度哮喘的关联及机制研究进展

doi:10.16138/j.1673-6087.2022.01.017

摘要/Abstract

关键词: 瘦素, 哮喘, 气道炎症, 气道重塑

中图分类号:

R562.25

王毅, 李红鹏, 张力月, 李庆云. 瘦素与重度哮喘的关联及机制研究进展[J]. 内科理论与实践, 2022, 17(01): 88-91.

参考文献 58

[1]	Stern J, Pier J, Litonjua AA. Asthma epidemiology and risk factors[J]. Semin Immunopathol, 2020, 42(1): 5-15. doi: 10.1007/s00281-020-00785-1 URL
[2]	Israel E, Reddel HK. Severe and difficult-to-treat asthma in adults[J]. N Engl J Med, 2017, 377(10): 965-976. doi: 10.1056/NEJMra1608969 URL
[3]	Agache I. Severe asthma phenotypes and endotypes[J]. Semin Immunol, 2019, 46: 101301. doi: 10.1016/j.smim.2019.101301 URL
[4]	Tashiro H, Shore SA. Obesity and severe asthma[J]. Allergol Int, 2019, 68(2): 135-142. doi: S1323-8930(18)30158-8 pmid: 30509734
[5]	Carpaij OA, van den Berge M. The asthma-obesity relationship: underlying mechanisms and treatment implications[J]. Curr Opin Pulm Med, 2018, 24(1): 42-49.
[6]	Bantulà M, Roca-Ferrer J, Arismendi E, et al. Asthma and obesity: two diseases on the rise and bridged by inflammation[J]. J Clin Med, 2021, 10(2): 169. doi: 10.3390/jcm10020169 URL
[7]	Vernooy JH, Drummen NE, van Suylen RJ, et al. Enhanced pulmonary leptin expression in patients with severe COPD and asymptomatic smokers[J]. Thorax, 2009, 64(1): 26-32. doi: 10.1136/thx.2007.085423 pmid: 18835960
[8]	Watanabe K, Suzukawa M, Arakawa S, et al. Leptin enhances cytokine/chemokine production by normal lung fibroblasts by binding to leptin receptor[J]. Allergol Int, 2019, 68S: S3-S8. doi: 10.1016/j.alit.2019.04.002 pmid: 31029506
[9]	Suzukawa M, Koketsu R, Baba S, et al. Leptin enhances ICAM-1 expression, induces migration and cytokine synthesis, and prolongs survival of human airway epithelial cells[J]. Am J Physiol Lung Cell Mol Physiol, 2015, 309(8): L801-L811. doi: 10.1152/ajplung.00365.2014 URL
[10]	Pérez-Pérez A, Vilariño-García T, Fernández-Riejos P, et al. Role of leptin as a link between metabolism and the immune system[J]. Cytokine Growth Factor Rev, 2017, 35: 71-84. doi: 10.1016/j.cytogfr.2017.03.001 URL
[11]	Zhang L, Yin Y, Zhang H, et al. Association of asthma diagnosis with leptin and adiponectin: a systematic review and meta-analysis[J]. J Investig Med, 2017, 65(1): 57-64. doi: 10.1136/jim-2016-000127 URL
[12]	Mikalsen IB, Byberg K, Forman MR, et al. Adipokines in adolescence; the associations with lung function and atopy—a cross-sectional study[J]. Respir Med, 2020, 170: 106063. doi: 10.1016/j.rmed.2020.106063 URL
[13]	Szczepankiewicz D, Sobkowiak P, Narozna B, et al. Leptin gene polymorphism affects leptin level in childhood asthma[J]. World J Pediatr, 2018, 14(6): 601-606. doi: 10.1007/s12519-018-0182-2 pmid: 30203371
[14]	Ma C, Wang Y, Xue M. Correlations of severity of asthma in children with body mass index, adiponectin and leptin[J]. J Clin Lab Anal, 2019, 33(6): e22915.
[15]	Nasiri Kalmarzi R, Ataee P, Mansori M, et al. Serum levels of adiponectin and leptin in asthmatic patients and its relation with asthma severity, lung function and BMI[J]. Allergol Immunopathol (Madr), 2017, 45(3): 258-264. doi: 10.1016/j.aller.2016.09.004 URL
[16]	Castro-Rodriguez JA, Forno E, Casanello P, et al. Leptin in cord blood associates with asthma risk at age 3 in the offspring of women with gestational obesity[J]. Ann Am Thorac Soc, 2020, 17(12): 1583-1589. doi: 10.1513/AnnalsATS.202001-080OC URL
[17]	Santos Coelho R, Paula Castro Melo A, Dos Santos Silva H, et al. ADIPOQ and LEP variants on asthma and atopy: genetic association modified by overweight[J]. Gene, 2021, 781: 145540. doi: 10.1016/j.gene.2021.145540 URL
[18]	Leão da Silva P, de Mello MT, Cheik NC, et al. Reduction in the leptin concentration as a predictor of improvement in lung function in obese adolescents[J]. Obes Facts, 2012, 5(6): 806-820. doi: 10.1159/000345840 URL
[19]	Li Z, Leynaert B, Dumas O, et al. Role of leptin in the association between body adiposity and persistent asthma[J]. Obesity (Silver Spring), 2019, 27(6): 894-898. doi: 10.1002/oby.22466 URL
[20]	Procaccini C, Jirillo E, Matarese G. Leptin as an immunomodulator[J]. Mol Aspects Med, 2012, 33(1): 35-45. doi: 10.1016/j.mam.2011.10.012 pmid: 22040697
[21]	Saucillo DC, Gerriets VA, Sheng J, et al. Leptin metabolically licenses T cells for activation to link nutrition and immunity[J]. J Immunol, 2014, 192(1): 136-144. doi: 10.4049/jimmunol.1301158 pmid: 24273001
[22]	Duvall MG, Barnig C, Cernadas M, et al. Natural killer cell-mediated inflammation resolution is disabled in severe asthma[J]. Sci Immunol, 2017, 2(9): eaam5446. doi: 10.1126/sciimmunol.aam5446 URL
[23]	Rastogi D, Fraser S, Oh J, et al. Inflammation, metabolic dysregulation, and pulmonary function among obese urban adolescents with asthma[J]. Am J Respir Crit Care Med, 2015, 191(2): 149-160. doi: 10.1164/rccm.201409-1587OC URL
[24]	Youssef DM, Elbehidy RM, Shokry DM, et al. The influence of leptin on Th1/Th2 balance in obese children with asthma[J]. J Bras Pneumol, 2013, 39(5): 562-568. doi: 10.1590/S1806-37132013000500006 URL
[25]	Mattioli B, Straface E, Quaranta MG, et al. Leptin promotes differentiation and survival of human dendritic cells and licenses them for Th1 priming[J]. J Immunol, 2005, 174(11): 6820-6828. doi: 10.4049/jimmunol.174.11.6820 URL
[26]	Moraes-Vieira PM, Larocca RA, Bassi EJ, et al. Leptin deficiency impairs maturation of dendritic cells and enhances induction of regulatory T and Th17 cells[J]. Eur J Immunol, 2014, 44(3): 794-806. doi: 10.1002/eji.201343592 pmid: 24271843
[27]	Dayakar A, Chandrasekaran S, Veronica J, et al. Leptin induces the phagocytosis and protective immune response in Leishmania donovani infected THP-1 cell line and human PBMCs[J]. Exp Parasitol, 2016, 160: 54-59. doi: 10.1016/j.exppara.2015.12.002 pmid: 26688099
[28]	Zheng H, Zhang X, Castillo EF, et al. Leptin enhances TH2 and ILC2 responses in allergic airway disease[J]. J Biol Chem, 2016, 291(42): 22043-22052. doi: 10.1074/jbc.M116.743187 URL
[29]	Zheng H, Wu D, Wu X, et al. Leptin promotes allergic airway inflammation through targeting the unfolded protein response pathway[J]. Sci Rep, 2018, 8(1): 8905. doi: 10.1038/s41598-018-27278-4 URL
[30]	Ramakrishnan RK, Al Heialy S, Hamid Q. Role of IL-17 in asthma pathogenesis and its implications for the clinic[J]. Expert Rev Respir Med, 2019, 13(11): 1057-1068. doi: 10.1080/17476348.2019.1666002 URL
[31]	Manni ML, Mandalapu S, McHugh KJ, et al. Molecular mechanisms of airway hyperresponsiveness in a murine model of steroid-resistant airway inflammation[J]. J Immunol, 2016, 196(3): 963-977. doi: 10.4049/jimmunol.1501531 URL
[32]	Agache I, Ciobanu C, Agache C, et al. Increased serum IL-17 is an independent risk factor for severe asthma[J]. Respir Med, 2010, 104(8): 1131-1137. doi: 10.1016/j.rmed.2010.02.018 pmid: 20338742
[33]	Dias ASO, Santos ICL, Delphim L, et al. Serum leptin levels correlate negatively with the capacity of vitamin D to modulate the in vitro cytokines production by CD4⁺ T cells in asthmatic patients[J]. Clin Immunol, 2019, 205: 93-105. doi: 10.1016/j.clim.2019.06.001 URL
[34]	Liang L, Hur J, Kang JY, et al. Effect of the anti-IL-17 antibody on allergic inflammation in an obesity-related asthma model[J]. Korean J Intern Med, 2018, 33(6): 1210-1223. doi: 10.3904/kjim.2017.207 pmid: 29665658
[35]	Qin L, Tan YR, Hu CP, et al. Leptin is oversecreted by respiratory syncytial virus-infected bronchial epithelial cells and regulates Th2 and Th17 cell differentiation[J]. Int Arch Allergy Immunol, 2015, 167(1): 65-71. doi: 10.1159/000436966 URL
[36]	Deng J, Liu Y, Yang M, et al. Leptin exacerbates collagen-induced arthritis via enhancement of Th17 cell response[J]. Arthritis Rheum, 2012, 64(11): 3564-3573. doi: 10.1002/art.34637 URL
[37]	Yu Y, Liu Y, Shi FD, et al. Cutting edge: leptin-induced RORγt expression in CD4⁺ T cells promotes Th17 responses in systemic lupus erythematosus[J]. J Immunol, 2013, 190(7): 3054-3058. doi: 10.4049/jimmunol.1203275 URL
[38]	Reis BS, Lee K, Fanok MH, et al. Leptin receptor signaling in T cells is required for Th17 differentiation[J]. J Immunol, 2015, 194(11): 5253-5260. doi: 10.4049/jimmunol.1402996 URL
[39]	Han W, Li J, Tang H, et al. Treatment of obese asthma in a mouse model by simvastatin is associated with improving dyslipidemia and decreasing leptin level[J]. Biochem Biophys Res Commun, 2017, 484(2): 396-402. doi: 10.1016/j.bbrc.2017.01.135 URL
[40]	Sun Z, Dragon S, Becker A, et al. Leptin inhibits neutrophil apoptosis in children via ERK/NF-κB-dependent pathways[J]. PLoS One, 2013, 8(1): e55249. doi: 10.1371/journal.pone.0055249 URL
[41]	Souza-Almeida G, D’Avila H, Almeida PE, et al. Leptin mediates in vivo neutrophil migration: involvement of tumor necrosis factor-alpha and CXCL1[J]. Front Immunol, 2018, 9: 111. doi: 10.3389/fimmu.2018.00111 pmid: 29467755
[42]	曹娟, 陈建辉, 朱述阳. 瘦素对支气管哮喘大鼠气道炎症及Th1/Th2细胞因子表达作用的影响[J]. 中华结核和呼吸杂志, 2009, 32(3): 171-176.
[43]	Lintomen L, Calixto MC, Schenka A, et al. Allergen-induced bone marrow eosinophilopoiesis and airways eosinophilic inflammation in leptin-deficient ob/ob mice[J]. Obesity (Silver Spring), 2012, 20(10): 1959-1965. doi: 10.1038/oby.2012.93 URL
[44]	Wong CK, Cheung PF, Lam CW. Leptin-mediated cytokine release and migration of eosinophils: implications for immunopathophysiology of allergic inflammation[J]. Eur J Immunol, 2007, 37(8): 2337-2348. doi: 10.1002/eji.200636866 URL
[45]	Kurokawa A, Kondo M, Arimura K, et al. Less airway inflammation and goblet cell metaplasia in an IL-33-induced asthma model of leptin-deficient obese mice[J]. Respir Res, 2021, 22(1): 166. doi: 10.1186/s12931-021-01763-3 URL
[46]	Mancuso P, Canetti C, Gottschalk A, et al. Leptin augments alveolar macrophage leukotriene synthesis by increasing phospholipase activity and enhancing group IVC iPLA2 (cPLA2gamma) protein expression[J]. Am J Physiol Lung Cell Mol Physiol, 2004, 287(3): L497-L502. doi: 10.1152/ajplung.00010.2004 URL
[47]	Chong L, Li H, Zhu L, et al. Regulatory effect of mitoQ on the mtROS-NLRP3 inflammasome pathway in leptin-pretreated BEAS-2 cells[J]. Exp Ther Med, 2021, 21(5): 466. doi: 10.3892/etm.2021.9897 pmid: 33763153
[48]	Bruno A, Pace E, Chanez P, et al. Leptin and leptin receptor expression in asthma[J]. J Allergy Clin Immunol, 2009, 124(2): 230-237. doi: 10.1016/j.jaci.2009.04.032 URL
[49]	何淑敏, 朱述阳, 李慧婷, 等. 瘦素对大鼠气道平滑肌细胞增殖的影响[J]. 细胞与分子免疫学杂志, 2011, 27(8): 849-851.
[50]	石瑞瑞, 陈显锋, 朱洁晨, 等. 瘦素促进低氧状态下大鼠气道平滑肌细胞增殖及HIF-1α、NF-κB表达[J]. 细胞与分子免疫学杂志, 2015, 31(1): 32-35.
[51]	刘文静, 朱述阳, 陈玉玲, 等. 瘦素通过PI3K/Akt通路对大鼠气道平滑肌细胞凋亡的影响[J]. 中华结核和呼吸杂志, 2012, 35(12): 915-918.
[52]	Schroeter MR, Leifheit M, Sudholt P, et al. Leptin enhances the recruitment of endothelial progenitor cells into neointimal lesions after vascular injury by promoting integrin-mediated adhesion[J]. Circ Res, 2008, 103(5): 536-544. doi: 10.1161/CIRCRESAHA.107.169375 pmid: 18658052
[53]	Yu F, Fu R, Liu L, et al. Leptin-induced angiogenesis of EA. Hy926 endothelial cells via the Akt and Wnt signaling pathways in vitro and in vivo[J]. Front Pharmacol, 2019, 10: 1275. doi: 10.3389/fphar.2019.01275 URL
[54]	Wang J, Leclercq I, Brymora JM, et al. Kupffer cells mediate leptin-induced liver fibrosis[J]. Gastroenterology, 2009, 137(2): 713-723. doi: 10.1053/j.gastro.2009.04.011 URL
[55]	Zibadi S, Cordova F, Slack EH, et al. Leptin’s regulation of obesity-induced cardiac extracellular matrix remodeling[J]. Cardiovasc Toxicol, 2011, 11(4): 325-333. doi: 10.1007/s12012-011-9124-0 URL
[56]	Zhang Z, Wang F, Wang BJ, et al. Inhibition of leptin-induced vascular extracellular matrix remodelling by adiponectin[J]. J Mol Endocrinol, 2014, 53(2): 145-154. doi: 10.1530/JME-14-0027 pmid: 24982243
[57]	Woo HJ, Yoo WJ, Bae CH, et al. Leptin up-regulates MUC5B expression in human airway epithelial cells via mitogen-activated protein kinase pathway[J]. Exp Lung Res, 2010, 36(5): 262-269. doi: 10.3109/01902140903427033 URL
[58]	Hao W, Wang J, Zhang Y, et al. Leptin positively regulates MUC5AC production and secretion induced by interleukin-13 in human bronchial epithelial cells[J]. Biochem Biophys Res Commun, 2017, 493(2): 979-984. doi: 10.1016/j.bbrc.2017.09.106 URL

瘦素与重度哮喘的关联及机制研究进展

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