目的：研究肝豆状核变性患者住院费用的影响因素,为卫生政策的制定提供依据。方法：回顾性收集2005至2020年首次入住四川大学华西第四医院肝豆状核变性患者的病历数据,使用多重线性回归明确肝豆状核变性患者住院费用的影响因素;使用协方差分析控制混杂因素明确自变量对住院费用的影响。SPSS 20.0（IBM）用于数据分析。结果：纳入346例肝豆状核变性患者,使用多重线性回归分析后发现就诊年份、年龄、合并症数量、住院天数及并发肝硬化失代偿可导致住院费用变化。控制混杂因素后,发现随着合并症数量的增加及并发肝硬化失代偿可导致住院费用增加,同时2005—2006及2007—2008年患者的住院费用较其他年份减少。结论：肝豆状核变性是一种慢性病,其住院费用受就诊年份、年龄、合并症数量、住院天数及并发肝硬化失代偿影响,需通过不断完善就诊流程、建立临床路径、纳入门诊特殊病管理、减少合并症及延缓肝硬化失代偿发生的时间,从而减少肝豆状核变性的疾病负担。

Objective To analyze the hospitalization cost of the patients with hepatolenticular degeneration in southwest of China. Methods The data of hospitalization cost of the patients with hepatolenticular degeneration were acquired from electronic medical record system in West China Fourth Hospital from 2005 to 2020. Multiple linear regression analysis was utilized for analyzing the factors of hospitalization cost retrospectively, and covariance analysis was used for controlling the confounding factors. SPSS 20.0 (IBM) was applied for data analysis. Results A total of 346 patients with hepatolenticular degeneration were enrolled in our analysis. The year of admission, age, number of comorbidities, days of hospitalization, and complication of decompensated liver cirrhosis were the factors to influence the cost of hospitalization. After the confounding factors were adjusted, the hospitalization cost grew following the increase of comorbidity number, and complication of decompensated liver cirrhosis also led to the increase of hospitalization cost. The hospitalization cost of 2005-2006 and 2007-2008 were lower than those in the rest of years. Conclusions Hospitalization cost of the patients with hepatolenticular degeneration in southwest of China were influenced by number of comorbidities, complication of decompensated liver cirrhosis, and year to admit. It was important to reduce the occurrence of complication and decompensated liver cirrhosis, as to reduce the cost of hospitalization.