论著

血管加压素与重症患者预后的相关性研究

展开
  • 1.南京医科大学第一附属医院a. 重症医学科;b. 心脏大血管外科,江苏 南京 210029
    2.南京医科大学第二附属医院消化医学中心,江苏 南京 210028
    3.南京医科大学附属儿童医院病理科,江苏 南京 210029

收稿日期: 2021-01-26

  网络出版日期: 2022-07-26

基金资助

国家自然科学基金项目(81900529)

Relationship between vasopressin and prognosis in the patients with critical condition

Expand
  • 1a. Department of Critical Care Medicine; b. Department of Cardiovascular Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029 China
    2. The Center of Digestive Medicine, the Second Affiliated Hospital of Nanjing Medical University, Nanjing 210028 China
    3. Department of Pathology, Children’s Hospital of Nanjing Medical University, Nanjing 210029, China

Received date: 2021-01-26

  Online published: 2022-07-26

摘要

目的:探讨血管加压素的使用对重症患者预后的影响。方法:回顾性分析美国重症医学信息监护数据集Ⅲ(Medical Information Mart for Intensive Care-Ⅲ,MIMIC-Ⅲ)重症患者的基本信息及临床资料,使用倾向性评分匹配法及COX多因素回归分析,探讨血管加压素对重症患者预后的影响。结果:共纳入MIMIC-Ⅲ中57 785例重症患者,其中有2 171例患者使用血管加压素。采用倾向性评分匹配方法对使用血管加压素治疗的患者和未使用血管加压素治疗的患者进行1∶1匹配,共1 168对患者匹配成功。匹配后使用血管加压素组与未使用血管加压素组相比,其院内死亡率、30 d死亡率、1年死亡率以及长期死亡率更高,住院时间及住重症监护病房(intensive care unit, ICU)时间均显著延长。COX多因素回归分析发现,血管加压素的使用是院内死亡率[风险比(hazard ratio, HR)=2.44, 95%置信区间(confidence interval,CI):2.147~2.772, P<0.001]、30 d死亡率(HR=2.205, 95%CI:1.940~2.505, P<0.001)、1年死亡率(HR=1.999, 95%CI:1.781~2.242, P<0.001)以及长期死亡率(HR=1.891, 95%CI:1.698~2.107, P<0.001)增加的独立危险因素。结论:本研究利用倾向性评分匹配法及COX多因素回归分析进行大样本回顾性研究,发现血管加压素的使用是影响重症患者预后的独立危险因素。

本文引用格式

李艳秀, 朱恩泽, 周春雷, 刘云, 左祥荣, 李京杭, 曹权 . 血管加压素与重症患者预后的相关性研究[J]. 内科理论与实践, 2021 , 16(03) : 183 -187 . DOI: 10.16138/j.1673-6087.2021.03.009

Abstract

Objective To investigate the effect of vasopressin on the prognosis in the patients with critical condition. Methods The basic information and clinical data of the patients in critical condition in American intensive care database Medical Information Mart for Intensive Care-Ⅲ(MIMIC-Ⅲ) were retrospectively analyzed. The influence of vasopressin on the prognosis of the patients in critical condition was investigated by propensity score matching method and Cox multivariate regression analysis. Results A total of 57 785 patients in critical condition were selected from the MIMIC-Ⅲ database, in which 2 171 were treated with vasopressin. Propensity matching method was used to match 1∶1 between the patients treated with vasopressin and the patients treated without vasopressin. A total of 1 168 patients were successfully matched. The mortality of in-hospital, 30 d, 1-year and long-term in the group using vasopressin were higher than the group treated without vasopressin after matching, and the time staying in hospital and intensive care unit (ICU) were significantly longer in the vasopressin group after matching. Cox multivariate regression analysis showed that using vasopressin was an independent risk factor for increased in-hospital mortality[hazard ratio(HR)=2.44, 95% confidence interval(CI): 2.147-2.772, P<0.001], 30 d mortality (HR=2.205, 95% CI:1.940-2.505, P<0.001), 1-year mortality (HR=1.999, 95% CI: 1.781-2.242, P<0.001) and long-term mortality (HR=1.891, 95% CI: 1.698-2.107, P<0.001). Conclusions This study used propensity score matching method and Cox multivariate regression analysis to conduct a large sample retrospective study, and showed that the using vasopressin is an independent risk factor for the prognosis of the patients with critical condition.

参考文献

[1] Cecconi M, De Backer D, Antonelli M, et al. Consensus on circulatory shock and hemodynamic monitoring[J]. Intensive Care Med, 2014, 40(12): 1795-1815.
[2] 邢适颖, 董平栓, 李志娟, 等. 去甲肾上腺素对感染性休克患者血流动力学与肾灌注的影响[J]. 中华医院感染学杂志, 2018, 28(19): 2905-2909.
[3] De Backer D, Biston P, Devriendt J, et al. Comparison of dopamine and norepinephrine in the treatment of shock[J]. N Engl J Med, 2010, 362(9): 779-789.
[4] Hammond DA, Ficek OA, Painter JT, et al. Prospective open-label trial of early concomitant vasopressin and norepinephrine therapy versus initial norepinephrine monotherapy in septic shock[J]. Pharmacotherapy, 2018, 38(5): 531-538.
[5] Johnson AE, Pollard TJ, Shen L, et al. MIMIC-Ⅲ, a freely accessible critical care database[J]. Sci Data, 2016, 3: 160035.
[6] Rhodes A, Evans LE, Alhazzani W, et al. Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016[J]. Intensive Care Med, 2017, 43(3): 304-377.
[7] 黄晓英, 韩旭东, 张素燕, 等. 垂体后叶素在感染性休克中对乳酸清除率及预后的影响[J]. 中国急救医学, 2012, 32(3): 206-208.
[8] 王忠和, 陈建朋, 胡湘福, 等. 垂体后叶素在脓毒性休克治疗中的应用[J]. 实用药物与临床, 2013, 16(12): 1179-1182.
[9] Jiang L, Sheng Y, Feng X, et al. The effects and safety of vasopressin receptor agonists in patients with septic shock: a meta-analysis and trial sequential analysis[J]. Crit Care, 2019, 23(1): 91.
[10] 中华医学会重症医学分会. 中国严重脓毒症/脓毒性休克治疗指南(2014)[J]. 中华内科杂志, 2015, 54(6): 557-581.
文章导航

/