奥马珠单抗对过敏性哮喘患者血清细胞因子谱的影响
收稿日期: 2023-05-16
网络出版日期: 2024-03-18
基金资助
国家自然科学基金项目(82170022)
Effect of omalizumab treatment on serum cytokine profile in allergic asthma patients
Received date: 2023-05-16
Online published: 2024-03-18
目的：探讨奥马珠单抗对过敏性哮喘患者血清细胞因子谱的影响。方法：纳入2019年1月至2021年1月在上海交通大学医学院附属瑞金医院呼吸与危重症医学科就诊并接受奥马珠单抗治疗的过敏性哮喘患者20例。收集奥马珠单抗治疗前及治疗4个月后患者肺功能数据，评估肺功能改善状况；采用电化学发光免疫分析法测定奥马珠单抗治疗前后患者血清中29个细胞因子水平，并比较其治疗前后的变化；采用哮喘控制测试（asthma control test，ACT）问卷评估哮喘控制改善状况；采用全球治疗有效性评估（global evaluation of treatment effectiveness，GETE）评分评估治疗有效性。结果：20例患者接受奥马珠单抗治疗4个月后，肺功能中平均用力呼出50%肺活量呼气流速（maximal expiratory flow at 50% of forced vital capacity，MEF50%）显著改善（P<0.05）；血清中辅助性T17细胞（helper T17 cell, Th17细胞）相关因子白细胞介素（interleukin，IL）-17A及IL-23水平显著上升（P<0.05），其余因子水平的改变差异无统计学意义；治疗后哮喘控制情况显著改善（P<0.01）；根据GETE评分，17例患者显效，3例不显效。结论：过敏性哮喘患者接受奥马珠单抗治疗后哮喘控制情况显著改善；Th17相关因子水平的上升及Th17细胞功能的恢复可能是奥马珠单抗的潜在治疗机制之一。
郑晓燕, 孙璘, 汤葳 . 奥马珠单抗对过敏性哮喘患者血清细胞因子谱的影响[J]. 内科理论与实践, 2023 , 18(06) : 388 -393 . DOI: 10.16138/j.1673-6087.2023.06.003
Objective To investigate the effect of omalizumab on serum cytokine profile in the patients with allergic asthma. Methods A total of 20 patients with allergic asthma who received omalizumab treatment in the Department of Pulmonary and Critical Care Medicine of Ruijin Hospital were enrolled in this study. Data of spirometry test was collected before and after 4 months of omalizumab treatment to evaluate the improvement of lung function. Serum samples before and after 4 months of omalizumab treatment were collected to measure 29 cytokines using Meso Scale Discovery(MSD). Asthma control was assessed by asthma control test (ACT) score and treatment effectiveness was evaluated by the Global Evaluation of Treatment Effectiveness (GETE) score. Results After 4 months of omalizumab treatment, maximal expiratory flow at 50% of forced vital capacity (MEF50) was significantly improved among 20 patients (P<0.05). Serum interleukin(IL)-17A and IL-23 levels were significantly increased(P<0.05). Asthma control was significantly improved(P<0.01). According to GETE score, omalizumab treatment was effective in 17 patients, but not effective in 3 patients. Conclusions Omalizumab treatment effectively improves asthma control in allergic asthmatics. Increased levels of helper T17 (Th17) cell -related cytokines and recovery of Th17 cell function may be one of the potential therapeutic mechanisms of omalizumab.
Key words： Omalizumab; Allergic asthma; Cytokines
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