目的：比较3种水化方式对预防异基因造血干细胞移植（allogeneic hematopoietic stem cell transplantation，allo-HSCT）后并发出血性膀胱炎（hemorrhagic cystitis，HC）的影响。方法：145例在我院行allo-HSCT的血液病患者随机分为A组（49例）、B组（48例）、C组（48例），A组为常规静脉和口服水化，B组为精细化静脉和口服水化，C组为除必要静脉用药外的精细化口服水化。对3组患者HC发生率、饮水依从性、饮水合格率和护理满意度进行比较。结果：HC发生率B组、C组低于A组（P<0.05），但B组与C组间差异无统计学意义（P>0.05）；饮水总依从率B组、C组高于A组（P<0.05）；护理满意度B组、C组高于A组（P<0.05）。结论：实施精细化水化方案的2组均可以降低HC发生率，提升患者饮水依从性，提升护理满意度。精细化口服水化更经济、安全，为血液病患者水化治疗的更优选择。

Objective To compare the effects of three hydration modalities on prevention of concomitant hemorrhagic cystitis (HC) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Methods One hundred and forty-five hematologic patients undergoing allo-HSCT in our hospital were randomly divided into group A (49 patients), group B (48 patients) and group C (48 patients), in which group A was treated by the conventional intravenous and oral hydration, group B was treated by the refined intravenous and oral hydration, and the group C received the treatment of refined oral hydration except for necessary intravenous medication. The occurrence of HC, water compliance, water qualification rate and nursing satisfaction were compared among three groups. Results The incidence of HC in groups B and C was lower than that in group A, but the difference between groups B and C was not statistically significant (P>0.05). The total compliance rates of drinking water in the patients of groups B and C were higher than that in group A (P<0.05); the nursing satisfaction of patients in groups B and C was higher than that in group A(P<0.05). Conclusions The refined hydration programmes can reduce the incidence of HC, improve compliance of drinking water and nursing satisfaction in the patient receiving allo-HSCT. The refined oral hydration is safer and more economical, which is a better choice for hydration treatment in the haematological patients.