结直肠癌预后生物标志物研究进展
Research progress on prognostic biomarkers for colorectal cancer
Received date: 2023-12-25
Online published: 2025-01-16
结直肠癌(colorectal carcinoma, CRC)是全球最常见的消化系统恶性肿瘤之一，流行病学统计显示，2020年全球CRC发病数居所有癌症发病数第3位，死亡率居第2位，其发病率增加的原因仍无明确定论，目前学界认为CRC的发生是一个多因素、多步骤的慢性过程，但因其起病隐匿，早期发现率低，多数患者因出现症状而就诊时多已处于疾病中晚期，导致其预后不良。我国CRC 5年平均生存率为56.9%，在周边亚太地区中处最低位，已对我国公民的生命健康造成巨大威胁，因而进一步了解CRC预后生物标志物对于推动CRC个体化治疗，以提高CRC患者的生存率与生存质量有重要作用。本文就CRC预后生物标志物研究新进展作一综述，以期对未来的CRC治疗有所启示。
王虹晓 , 苏琪莹 , 阎骅 . 结直肠癌预后生物标志物研究进展[J]. 内科理论与实践, 2024 , 19(05) : 337 -341 . DOI: 10.16138/j.1673-6087.2024.05.10
Colorectal cancer (CRC) is one of the most common malignant tumors of digestive system in the world. Epidemiological statistics showed that the global incidence of CRC ranked third among all cancer types and its mortality rate ranked second in 2020, while the reasons for the increased incidence are still not clear. At present, it is believed that the occurrence of CRC is a multi-factor and multi-step chronic process. Because the onset of CRC is insidious and the early detection rate is low, most patients are diagnosed in the middle and late stage as symptoms develop, which leads to poor prognosis. The average 5-year survival rate of CRC in China was 56.9%, which was the lowest among surrounding Asia-Pacific countries. CRC has become a huge threat to the life and health of Chinese citizens. Therefore, further understanding of prognosis biomarkers of CRC are important in promoting individualized treatment and improving the survival rate and quality of life in CRC patients. This article reviews the research progress on prognostic biomarkers for CRC to provide some inspiration for future treatment of CRC.
Key words： Colorectal cancer; Prognosis; Biomarkers; Monitoring
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