内科理论与实践

内科理论与实践 >

2024 , Vol. 19 >Issue 06: 422 - 426

DOI: https://doi.org/10.16138/j.1673-6087.2024.06.13

综述

间充质干细胞在系统性风湿病中的应用：现状与前景

  • 苏传昕 ,
  • 朱振航 ,
  • 王旺 ,
  • 梁容珍 ,
  • 郑颂国 ,
  • 赵福涛
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  • 1.上海交通大学医学院松江医院风湿免疫科 细胞和基因研究院 松江研究院,上海 201600
    2.上海交通大学医学院附属第九人民医院免疫风湿科,上海 200011
郑颂国 E-mail：Song.Zheng@shsmu.edu.cn;
赵福涛 E-mail：ftzhao@moisten.org

收稿日期: 2024-11-22

  网络出版日期: 2025-03-11

基金资助

松江区科技攻关项目(2024SJKJGG070);上海市卫生健康委员会科研项目(202140411)

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Application of mesenchymal stem cells in systemic rheumatic diseases: current situation and prospects

  • SU Chuanxin ,
  • ZHU Zhenhang ,
  • WANG Wang ,
  • LIANG Rongzhen ,
  • ZHENG Songguo ,
  • ZHAO Futao
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  • 1. Department of Rheumatology and Immunology, School of Cell and Gene Therapy， Songjiang Research Institute, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 201600, China
    2. Department of Rheumatology and Immunology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China

Received date: 2024-11-22

  Online published: 2025-03-11

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摘要

间充质干细胞（mesenchymal stem cell，MSC）作为一种具有多向分化能力和免疫调节特性的细胞类型，近年来在系统性风湿病的治疗中受到广泛关注。系统性风湿病包括系统性红斑狼疮（systemic lupus erythematosus，SLE）、类风湿性关节炎（rheumatoid arthritis，RA）、强直性脊柱炎（ankylosing spondylitis，AS）和干燥综合征（Sjögren syndrome，SS）等，这些疾病常导致患者生活质量显著下降，且现有治疗手段存在局限性。因此，探索MSC在这些疾病中的应用具有重要意义。现有研究表明，MSC可通过调节免疫反应、促进组织修复及减轻炎症等多种机制发挥治疗作用。然而，尽管部分临床研究已表明MSC在系统性风湿病中的潜在疗效，仍存在细胞来源选择、治疗方案优化及长期安全性评估等问题亟待解决。本文旨在系统回顾MSC在系统性风湿病中的应用现状，分析其疗效及安全性，并展望未来研究方向，以期为该领域发展提供参考。

关键词： 间充质干细胞; 系统性风湿病; 系统性红斑狼疮; 干燥综合征

本文引用格式

苏传昕 , 朱振航 , 王旺 , 梁容珍 , 郑颂国 , 赵福涛 . 间充质干细胞在系统性风湿病中的应用：现状与前景[J]. 内科理论与实践, 2024 , 19(06) : 422 -426 . DOI: 10.16138/j.1673-6087.2024.06.13

Abstract

Mesenchymal stem cell (MSC), a type of cell with the ability to differentiate into multiple lineages and immunomodulatory properties, have gained widespread attention in the treatment of systemic rheumatic diseases recently. Systemic rheumatic diseases such as systemic lupus erythematosus, rheumatoid arthritis, ankylosing spondylitis, and Sjögren syndrome often led to a significant decline in patients’ quality of life, while current treatment methods have limitations. Therefore, it’s important to explore new method, and the application of MSC in these diseases has great significance. Current research indicates that MSC can exert therapeutic effects through various mechanisms, including regulating immune responses, promoting tissue repair, and reducing inflammation, and some clinical studies have showed the potential efficacy of MSC in systemic rheumatic diseases. However, many issues still need to be addressed, such as the source of cells, optimization of treatment protocols, and long-term safety assessments. This article systematically reviews the current application status of MSC in systemic rheumatic diseases, analyze their efficacy, safety, and future research directions, to provide a reference for development in this field.

Key words： Mesenchymal stem cell; Systemic rheumatic diseases; Systemic lupus erythematosus; Sjögren syndrome

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