Clinical effect of Kou Chuang San in treating oral mucositis associated with chemotherapy in malignant hematologic patient after autologous stem cell transplantation

doi:10.16138/j.1673-6087.2025.01.03

Journal of Internal Medicine Concepts & Practice ›› 2025, Vol. 20 ›› Issue (01): 14-17.doi: 10.16138/j.1673-6087.2025.01.03

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Clinical effect of Kou Chuang San in treating oral mucositis associated with chemotherapy in malignant hematologic patient after autologous stem cell transplantation

TANG Wei^a, CAI Mingci^a, SHEN Yige^a, ZHANG Shoujie^b, GE Jian^c(), ZHAO Weili^a()

a. Department of Hematology,Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine; b. Department of Traditional Chinese Medicine; c. Depowtment of Ophthalmology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

Received:2023-12-04 Online:2025-02-28 Published:2025-04-30

Abstract

Abstract:

Objective To study clinical effect with Kou Chuang San in oral mucositis associated with chemotherapy in malignant hematologic patient during autologous stem cell transplantation. Methods From April 2016 to December 2021,149 patients with oral mucositis who received autologous hematopoietic stem cell transplantation in the Department of Hematology in Ruijin hospital were enrolled and divided into two groups according to receiving Kou Chuang San treatment or not. The treatment group was applied to Kou Chuang San on the first day after stem cell transplantation, while the patients who did not receive Kou Chuang San treatment belonged to the control group. Oral mucositis grading and therapeutic effects were compared between the two groups. Results The incidence of oral mucositis in the treatment group was significantly lower than that in the control group (87.18% vs 6.25%, P<0.001). Conclusions The Kou Chuang San is effective and safe in treating patients with oral mucositis after autologous hematopoietic stem cell transplantation.

Key words: Autologous stem cell transplantation, Oral mucositis, Kou Chuang San

CLC Number:

R781.5

TANG Wei, CAI Mingci, SHEN Yige, ZHANG Shoujie, GE Jian, ZHAO Weili. Clinical effect of Kou Chuang San in treating oral mucositis associated with chemotherapy in malignant hematologic patient after autologous stem cell transplantation[J]. Journal of Internal Medicine Concepts & Practice, 2025, 20(01): 14-17.

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References 8

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临床特征	对照组（n=74）	口疮散治疗组（n=75）	t/χ²	P
年龄（岁）	45±18	48±14	1.553	0.123
性别[n（%）]			0.923	0.337
男性	50（67.6）	45（60.0）
女性	24（32.4）	30（40.0）
诊断[n（%）]			3.101	0.212
霍奇金淋巴瘤	5（6.8）	10（13.3）
B细胞非霍奇金淋巴瘤	62（83.8）	54（72.0）
T细胞非霍奇金淋巴瘤	7（9.4）	11（14.7）
Ann-Arbor分期[n（%）]			2.106	0.143
Ⅰ+Ⅱ	18（24.3）	26（34.6）
Ⅲ+Ⅳ	56（75.7）	49（65.4）
ECOG评分[n（%）]			1.203	0.273
0~1分	69（93.2）	66（88.0）
2~4分	5（6.8）	9（12.0）
乳酸脱氢酶>192 U/L[n（%）]	48（64.8）	45（60.0）	0.581	0.449
放疗[n（%）]	21（28.4）	26（34.7）	0.682	0.409
移植前疾病状态[n（%）]			1.086	0.581
CR1	40（54.1）	43（57.3）
CR2	25（33.8）	20（26.7）
PR	9 （12.1）	12（16.0）
体重（kg）	69.0±14.5	69.3±17.5	0.155	0.877
回输CD34⁺细胞（×10⁶/kg）	3.6±1.8	4.1±2.3	1.526	0.129

组别	Ⅰ度	Ⅱ度	Ⅲ度	Ⅳ度	Z	P
对照组（n=74）	18	16	8	6	-0.414	0.679
治疗组（n=75）	16	13	6	4

组别	Ⅰ度	Ⅱ度	Ⅲ度	Ⅳ度
对照组（n=48）
痊愈	2	1	0	0
未愈	16	15	8	6
治疗组（n=39）
痊愈	16	11	5	2
未愈	0	2	1	2

Clinical effect of Kou Chuang San in treating oral mucositis associated with chemotherapy in malignant hematologic patient after autologous stem cell transplantation

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