Journal of Internal Medicine Concepts & Practice >

2021 , Vol. 16 >Issue 06: 392 - 396

DOI: https://doi.org/10.16138/j.1673-6087.2021.06.005

Original article

Effect of selenium yeast combined with vitamin D on thyroid-associated antibody levels in patients with Hashimoto thyroiditis at different ages

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  • Department of Endocrinology, Halison International Peace Hospital, Hengshui 053000, China

Received date: 2020-11-24

  Online published: 2022-07-25

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Abstract

Objective To investigate the effect of selenium yeast combined with vitamin D on thyroid related antibody levels in Hashimoto thyroiditis (HT) patients at different ages. Method In this study, 148 patients with HT (96 adults and 52 minors) were selected from December 2017 to December 2019. The patients were divided into control group and observation group. The patients in the control group were treated with routine methods and the observation group of patients used selenium yeast and vitamin D besides routine treatment. After 6 months, the levels of thyroid peroxidase autoantibody (TPOAb) and thyroglobulin antibody (TgAb) before and after treatment were compared between two groups. Results Serum 25-hydroxyvitamin D3 [25(OH) D3] levels were detected in both adults and minors before combined treatment. The average 25(OH) D3 level in 2 groups before treatment was lower than normal, while the 25(OH) D3 level in minors was higher than that in adults (P<0.05). There was no significant difference in TPOAb and TgAb in control group and the observation group before treatment(P>0.05). The levels of TPOAb and TgAb in the observation group were significantly lower than those in the control group(P<0.05), in addition, the treatment effect of the observation group was significantly higher than that of the control group(P<0.05). Conclusions The treatment of HT with selenium yeast combined with vitamin D on the basis of routine treatment can effectively reduce the TPOAb and TgAb level in adult and minor patients. The therapeutic effect is remarkable and has application value in the clinic.

Key words： Selenium yeast; Vitamin D; Age stratification; Hashimoto thyroiditis; Thyroid peroxidase autoantibody; Thyroglobulin antibody

Cite this article

GU Wei, HOU Liping, LI Xiaolong, GENG Jianlin . Effect of selenium yeast combined with vitamin D on thyroid-associated antibody levels in patients with Hashimoto thyroiditis at different ages[J]. Journal of Internal Medicine Concepts & Practice, 2021 , 16(06) : 392 -396 . DOI: 10.16138/j.1673-6087.2021.06.005

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