Journal of Internal Medicine Concepts & Practice >
Risk factors of asymptomatic erosive esophagitis
Received date: 2020-12-23
Online published: 2022-07-26
Objective To explore the prevalence, risk factors, prognosis, and management of asymptomatic erosive esophagitis(AEE). Methods A total of 5 184 asymptomatic individuals who underwent gastroscopy for routine health checkup were included in our study. 475 (9.2%) patients with EE devoid of gastroesophageal reflux disease(GERD) symptoms were selected as AEE group. A total of 950 age- and gender-matched subjects with negative endoscopic findings were selected as healthy control group. The clinical data between the two groups were compared. The independent risk factors, prognosis, and treatment of AEE were analyzed. Results A higher body mass index (BMI) [odds ratio(OR)=1.101, P=0.001], fatty liver(OR=1.635, P=0.013), hiatus hernia(OR=2.302, P=0.039), and higher gamma-glutamyl transferase (GGT)(OR=1.008, P=0.013) were independent risk factors for AEE. A total of 140 patients were followed up after they were diagnosed with AEE. Regardless of treatment, improved esophagitis occurred in about 2/3 AEE patients(82.4% vs 65.3%). However, the proportion of subjects with improved esophagitis was much higher in the proton pump inhibitor(PPI) treatment group than that in the non-treatment group. Conclusions Higher BMI, fatty liver, hiatus hernia, and higher GGT are independent risk factors for AEE. The prognosis of AEE is good and PPI treatment could improve AEE.
SUN Chao, YAO Weiyan, HUANG Jia, ZHU Ying, TANG Yuming . Risk factors of asymptomatic erosive esophagitis[J]. Journal of Internal Medicine Concepts & Practice, 2021 , 16(03) : 188 -192 . DOI: 10.16138/j.1673-6087.2021.03.010
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