Journal of Internal Medicine Concepts & Practice >

2022 , Vol. 17 >Issue 04: 301 - 306

DOI: https://doi.org/10.16138/j.1673-6087.2022.04.006

Original article

A retrospective cohort study on the correlation between triglyceride-glucose index and new-onset fatty liver disease

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  • 1. School of Nursing, Shanghai Jiao Tong University, Shanghai 200025, China
    2a. Physical Examination Center; b. Nursing Department, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

Received date: 2021-12-06

  Online published: 2022-08-08

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Abstract

Objective To explore the correlation between triglyceride-glucose(TyG) index and new-onset fatty liver disease(FLD) to provide references for the prevention and treatment of FLD. Methods This retrospective cohort study recruited the subjects received physical examination at the physical examination center of our hospital in 2018 by convenience sampling. The participants were divided into four groups according to the quartiles of TyG index: Q1, Q2, Q3, Q4, and they were followed up each year until 2020. A cohort of 958 subjects were included for final analysis. The Cox proportional-hazards regression model and Spearman correlation were used to analyze the association between the TyG index and new-onset FLD. Results The cumulative incidence of FLD increased along with the increase of TyG (P<0.05). After adjusting for multiple factors such as age, gender and body mass index(BMI) with the Cox proportional-hazards regression model, the incidence of FLD in the Q2, Q3, Q4 groups was 2.107 times [95% confidence interval (CI): 1.317-3.373], 2.598 times (95%CI: 1.659-4.069), 3.171 times(95%CI: 2.036-4.938) higher than that in the Q1 group. The Spearman correlation analysis revealed that the TyG index is highest positively related to the new-onset FLD (r=0.302, P<0.001). Conclusions The risk of FLD increased with the increase of TyG, which could be an effective indicator to predict the incidence of FLD.

Key words： Fatty liver; Triglyceride-glucose index; Cohort study

Cite this article

XU Doudou, CHEN Ying, LÜ Ankang, WU Beiwen . A retrospective cohort study on the correlation between triglyceride-glucose index and new-onset fatty liver disease[J]. Journal of Internal Medicine Concepts & Practice, 2022 , 17(04) : 301 -306 . DOI: 10.16138/j.1673-6087.2022.04.006

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