Objective To explore the risk factors of falls in the patients receiving peritoneal dialysis and provide the basis for their safety managements. Methods A total of 147 patients receiving peritoneal dialysis who matched the requirements from January to December 2019 in the peritoneal dialysis clinic of our hospital were selected. In one year, the incidence of falls was retrospectively investigated through every three months’ evaluation. The Logistic multiple regression was used to analyze the independent risk factors of falls in these patients. Results A total of 51 falls occurred in 32 cases in one year, and the fall rate was 21.8%. The patients were divided into two groups, which were fall group and non-fall group. Comparing fall group with non-fall group, the risk factors for falls were as follows: diabetes (7.8% vs 21.9%, P=0.048), dialysis age [26.0 (11.0, 49.3) months vs 44.4(24.1, 76.8) months, P=0.002], endogenous creatinine clearance rate (CCR)[58.61(50.85,79.16) L/week vs 51.53 (45.39, 59.50) L/week, P=0.001], albumin [(36.6±4.1) g/L vs (34.9±4.3) g/L, P=0.047], phosphorus [1.6 (1.4, 1.9) mmol/L vs 1.7 (1.5, 2.2) mmol/L, P=0.05], 24-hour urine volume [700(60,1 100) mL/24h vs 75(0, 488) mL/24h, P=0.002], ultrafiltration volume of dialysate[600(300, 900) mL/24h vs 800(472,1 160) mL/24h, P=0.002], number of antihypertensive drugs (≤3: 80.9% vs 56.3%, ≥4: 19.1% vs 43.8%, P=0.004 2), amobility (no help 98.3% vs 87.5%, help or crutch 0 vs 12.5% and wheelchair 1.7% vs 0, P=0.021). The Logistic multiple regression analysis showed that diabetes [odds ratio(OR)=6.569, P=0.007], dialysis age(OR=1.022, P=0.011), blood phosphorus(OR=3.372, P=0.024), the use of antihypertensive drugs(OR=3.601, P=0.015), 24-hour urine volume（OR=1.001, P=0.039） were independent risk factors for falls. Conclusions The falls in the patient receiving peritoneal dialysis is the result of multiple factors, and it’s important to adopt necessary measures to prevent falls in these patients.