Original article

Inflammation mediate correlation of body mass index and arteriosclerosis

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  • Department of Cardiology, the First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China

Received date: 2021-07-16

  Online published: 2023-05-15

Abstract

Objective To investigate if the inflammation mediated the association of body mass index(BMI) and the atherosclerosis. Methods A total of 4 508 subjects were randomly recruited from Gaoyou, and the indexes including the demographic characteristics, BMI, blood routine, biochemical test, disease history and brachial-ankle pulse wave velocity (baPWV) were measured. According to BMI, they were divided into low body weight group(BMI<18.5 kg/m2), normal weight group (18.5 kg/m2≤BMI<24 kg/m2), overweight group (24 kg/m2≤BMI<28 kg/m2) and obesity group (BMI≥28 kg/m2). The univariate and multivariate linear regression analysis was used to analyze the correlation between BMI and baPWV. The mediation analysis was used to evaluate whether white blood cell count was involved in the correlation between BMI and baPWV. Results After adjustment of age, gender, systolic blood pressure, fasting blood glucose, total cholesterol, low density lipoprotein cholesterol, alanine aminotransferase, aspartate aminotransferase, creatinine, smoking, drinking, diabetes and antihypertensive treatment, compared with normal weight group, the regression coefficient and 95% confidence interval of low body weight group, overweight, obesity group with baPWV were 1.01(0.51-1.51), -0.12(-0.27-0.02) and -0.28(-0.49- -0.08), respectively. The mediation analysis showed that white blood cell count mediated the correlation of BMI and baPWV, the mediation percentage of low body weight, overweight and obesity groups were 3.3%, 11.4% and 9.8%, respectively(all P<0.05). Conclusions The people of low weight could have a higher risk of atherosclerosis, and the inflammation might mediate the correlation between BMI and arterial stiffness.

Cite this article

MA Mengzhen, GONG Huanhuan, WANG Qin, ZHOU Fang . Inflammation mediate correlation of body mass index and arteriosclerosis[J]. Journal of Internal Medicine Concepts & Practice, 2023 , 18(02) : 83 -86 . DOI: 10.16138/j.1673-6087.2023.02.004

References

[1] Laurent S, Boutouyrie P, Asmar R, et al. Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients[J]. Hypertension, 2001, 37(5): 1236-1241.
[2] 唐世凡, 董晓雁, 程锡华, 等. 踝臂脉搏波速对冠心病的预测及筛查价值[J]. 临床心血管病杂志, 2017, 33(12): 1186-1189.
[3] 桑玉, 阮磊, 杨雪雪, 等. 中青年人群肱踝脉搏波传导速度分布与早发血管衰老[J]. 临床心血管病杂志, 2019, 35(7):634-638.
[4] Kim HL, Kim SH. Pulse wave velocity in atherosclerosis[J]. Front Cardiovasc Med, 2019, 6:41.
[5] Laurent S, Cockcroft J, Van Bortel L, et al. Expert consensus document on arterial stiffness: methodological issues and clinical applications[J]. Eur Heart J, 2006, 27(21): 2588-2605.
[6] Ninomiya T, Kojima I, Doi Y, et al. Brachial-ankle pulse wave velocity predicts the development of cardiovascular disease in a general Japanese population[J]. J Hypertens, 2013, 31(3): 477-483.
[7] Ishisone T, Koeda Y, Tanaka F, et al. Comparison of utility of arterial stiffness parameters for predicting cardiovascular events in the general population[J]. Int Heart J, 2013, 54(3): 160-165.
[8] Yang H, Zhao J, Deng X, et al. Pulse wave velocity is decreased with obesity in an elderly Chinese population[J]. J Clin Hypertens (Greenwich), 2019, 21(9): 1379-1385.
[9] Tang B, Luo F, Zhao J, et al. Relationship between body mass index and arterial stiffness in a health assessment Chinese population[J]. Medicine (Baltimore), 2020, 99(3): e18793.
[10] Lee YJ, Lee JW, Kim JK, et al. Elevated white blood cell count is associated with arterial stiffness[J]. Nutr Metab Cardiovasc Dis, 2009, 19(1): 3-7.
[11] 黄亚廷, 王琴, 高媛, 等. 成人BMI与踝臂指数的相关性分析[J]. 临床心血管病杂志, 2021, 37(3): 268-271.
[12] 张海锋, 朱桢燕, 姚文明, 等. 江苏高邮市农村居民心房颤动流行现况及危险因素研究[J]. 临床心血管病杂志, 2010, 26(10): 773-775.
[13] Mu?oz Aguilera E, Leira Y, Miró Catalina Q, et al. Is systemic inflammation a missing link between periodontitis and hypertension?[J]. J Intern Med, 2021, 289(4):532-546.
[14] Li A, Chen Y, van der Sluis LWM, et al. White blood cell count mediates the association between periodontal inflammation and cognitive performance measured by digit symbol substitution test among older U.S. adults[J]. J Gerontol A Biol Sci Med Sci, 2021, 76(7): 1309-1315.
[15] 王秋云, 陈桢玥. 血小板和炎症在动脉硬化血栓形成中的研究进展[J]. 内科理论与实践, 2017, 12(3): 212-215.
[16] Kim M, Yoo HJ, Kim M, et al. Associations among oxidative stress, Lp-PLA2 activity and arterial stiffness according to blood pressure status at a 3.5-year follow-up in subjects with prehypertension[J]. Atherosclerosis, 2017, 257: 179-185.
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