Objective To explore the teaching method based on computer-aided teaching mode in the clinical learning dyslipidemia for general practice residents. Methods A total of 42 residents who participated in standardized training for general practice residents at our hospital from July in 2019 to August in 2022 were selected as the research subjects. They were randomly divided into a reference group and a research group. The reference group learned dyslipidemia through traditional teaching methods while the research group learned it through a computer-aided teaching mode. Before and after the course, the basic theoretical knowledge assessment and clinical case application analysis assessment in two groups were performed and the scores were compared. In addition, a questionnaire survey was conducted to evaluate how well the residents learned the key points of dyslipidemia, their subjective learning attitude, and their acceptance of application of computer-aided teaching mode in general practice. Results In research group, the basic theoretical knowledge（40.52±2.93 vs 37.86±5.20）, clinical practical case analysis scores(39.95±2.84 vs 36.24±3.94), and score increase of basic theoretical knowledge and clinical practical case analysis after learning (11.67±4.37 vs 7.86±5.57; 13.00±3.69 vs 8.14±4.95) were higher than those in reference group and showed statistical differences(P<0.05). Compared to reference group, the scores in research group were significantly higher in terms of learning key point of dyslipidemia (35.48±1.33 vs 29.29±1.85）, the subjective learning attitude(25.81±1.25 vs 21.05±0.97), and acceptance of computer-aided teaching mode (27.95±0.80 vs 18.33±1.15) in general practice (P<0.05). Conclusions The teaching method based on computer-aided teaching mode is superior to traditional teaching methods in clinical learning of dyslipidemia for general practitioners. Besides，it can also improve basic theoretical knowledge learning and clinical comprehensive ability in practical application, and it’s easy to be acceptable by general practitioners.