Objective To identify the classification characteristics of sleep quality in liver cirrhosis patients, and explore the difference of quality of life(QOL) among the patients with different sleep quality categories. Methods A total of 221 liver cirrhosis patients in the infectious disease department of our hospital were selected as the research subjects from June 2020 to June 2021 by using convenient sampling method, in which Pittsburgh sleep quality index (PSQI) and chronic liver disease questionnaire(CLDQ) were investigated. Results According to sleep quality，the patients with liver cirrhosis were divided into 4 potential categories, which were sleep disorder group (24.4%), good sleep quality group (43.9%), lack of sleep group (12.7%) and prolonged sleep latency-daytime sleepy group (19.0%); and the incidence of sleep disturbance in 4 groups was 98.2%, 4.1%, 60.7% and 76.2%, respectively. Using good sleep quality group as reference, the score of QOL among the other groups of potential categories showed significant difference (P<0.05); the multiple linear stepwise regression suggested that daytime dysfunction, poor subjective sleep quality and sleep disorder were the main sleep problems affecting life quality(P<0.05). Conclusions There is heterogeneity in the sleep quality of cirrhosis patients, and the decreased QOL is generally consistent with poor sleep quality. It is necessary to learn the characteristics and differences of different sleep quality categories and improve the quality of sleep and life through targeted intervention.