Journal of Internal Medicine Concepts & Practice >

2024 , Vol. 19 >Issue 01: 31 - 35

DOI: https://doi.org/10.16138/j.1673-6087.2024.01.06

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Importance of drug monitoring for compound sulfamethoxazole therapy in patients with Pneumocystis jiroveci pneumonia

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  • a. Department of Pharmacy, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    b. Pulmonary and Critical Care Medicine, Institute of Respiratory Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

Received date: 2023-10-26

  Online published: 2024-04-28

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Abstract

Pneumocystis jiroveci pneumonia (PJP) is one of the more common and serious opportunistic infections in patients with human immunodeficiency virus (HIV). With the use of immunosuppressants and chemotherapy drugs, most PJP cases reported in China are non-HIV immunosuppressed patients. Compound sulfamethoxazole (SMZco) is the first-line drug for the treatment of PJP, and there are wide individual differences in its pharmacokinetics. Through citing a PJP case treated with SMZco under drug monitoring, a systematic review was conducted from the aspects of SMZco pharmacokinetics, dose-related adverse reactions, and optimal therapeutic dose research. It aims to demonstrate the importance of drug monitoring for sulfamethoxazole therapy, which ensures the drug reaches effective therapeutic concentrations and the occurrence of its’ adverse reactions was reduced.

Key words： Pneumocystis jiroveci pneumonia; Compound sulfamethoxazole; Therapeutic drug monitoring

Cite this article

FANG Jie, CHEN Chao, ZHOU Min . Importance of drug monitoring for compound sulfamethoxazole therapy in patients with Pneumocystis jiroveci pneumonia[J]. Journal of Internal Medicine Concepts & Practice, 2024 , 19(01) : 31 -35 . DOI: 10.16138/j.1673-6087.2024.01.06

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