The 45-year-old male patient had uremia due to gout and hypertension in the past and underwent kidney transplantation, currently complicated with renal insufficiency. To prevent rejection, the patient administrated mycopherol sodium enteric-covered tablets 540 mg，twice a day, tacrolimus 1 mg in the morning and 2 mg in the evening and methylprednisolone 4 mg orally for long-term. Nifedipine controlled release tablets (30 mg, twice a day) were used for hypertension. Following a diagnosis of depression 3 years ago， medication was commenced with trazodone (50 mg, twice a day) and quetiapine fumarate (200 mg, twice a day) orally. The patient got novel coronavirus infection and was cured in December 2022. The plaque psoriasis was diagnosed in January 2023, and the treatment effect of oral anti-allergy drugs and topical hormone symptomatic treatment was not good for him. After being admitted to the hospital and receiving treatment of secukinumab 300 mg, psoriasis area and severity index (PASI) score and dermatology life quality index(DLQI) score of the patient were significantly improved, and he also showed well tolerated. The treatment of the case provides reference for the similar patients with psoriasis complicated with renal insufficiency.