Journal of Internal Medicine Concepts & Practice >
Study on correlation between nutritional risk assessment and clinical outcome in hospitalized patients with cirrhosis
Received date: 2024-08-07
Online published: 2025-12-26
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Objective To evaluate the nutritional risk in hospitalized patients with cirrhosis and explore the relationship between nutritional risk and clinical prognosis. Methods A total of 401 patients with cirrhosis admitted to the infectious diseases department of a grade-Ⅲ hospital in Shanghai from June 2020 to June 2022 were selected as study subjects. The nutritional risk assessment was performed using the Royal Free Hospital-nutrition prioritizing tool (RFH-NPT), and the general information, disease status, laboratory indicators, and clinical prognosis of cirrhosis patients with different nutritional risks were compared. Results In 401 patients, 86 (21.45%) cases had moderate nutritional risk, and 122 (30.42%) cases had high nutritional risk. There were differences in etiological classification, model for end-stage liver disease (MELD) score, Child-Pugh grade, abdominal water volume and laboratory indexes of serum albumin, prealbumin, triglyceride and hemoglobin among patients with different nutritional risks (P < 0.05). With the increase of nutritional risk grade, the incidence of infection, upper gastrointestinal bleeding and electrolyte disturbance increased, and the score of activity of daily living decreased (P < 0.05). Conclusions Cirrhosis patients with moderate to high nutritional risk have severer liver function impairment, high complication rate and poor clinical prognosis compared to those at lower risk.
Key words： Liver cirrhosis; Nutritional risk; Clinical outcome; RFH-NPT
WANG Lin , XIANG Xiaogang , LI Li , QIAN Zhuping . Study on correlation between nutritional risk assessment and clinical outcome in hospitalized patients with cirrhosis[J]. Journal of Internal Medicine Concepts & Practice, 2025 , 20(05) : 376 -380 . DOI: 10.16138/j.1673-6087.2025.05.05
| [1] | Shah ND, Barritt AS 4th. Nutrition as therapy in liver disease[J]. Clin Ther, 2022, 44(5): 682-696. |
| [2] | Aller de la Fuente R. Nutrition and chronic liver disease[J]. Clin Drug Investig, 2022, 42(Suppl 1): 55-61. |
| [3] | Gon?alves F, Cabral S, Moreira AP, et al. Characterization and monitoring of nutritional risk and nutritional status in oncological patients admitted to an oncological surgery unit: a longitudinal study[J]. Clin Nutr ESPEN, 2023, 57: 637-646. |
| [4] | Bellanti F, Lo Buglio A, Quiete S, et al. Malnutrition in hospitalized old patients: screening and diagnosis, clinical outcomes, and management[J]. Nutrients, 2022, 14(4): 910. |
| [5] | 熊万银, 高莉. 营养支持小组在肝硬化病人营养管理中的应用效果分析[J]. 全科护理, 2022, 20(5): 619-621. |
| Xiong WY, Gao L. Effect of a nutrition support team on the nutritional management of patients with cirrhosis[J]. Chinese General Practice Nursing, 2022, 20(5): 619-621. | |
| [6] | 中华医学会肝病学分会. 肝硬化诊治指南[J]. 实用肝脏病杂志, 2019, 22(6): 770-786. |
| Chinese Society of Hepatology. Chinese guidelines on the management of cirrhosis[J]. J Prac Hepatol, 2019, 22(6): 770-786. | |
| [7] | Glasenapp JH, Zuchinali P, Alba VD. Translation and cross-cultural adaptation of the Royal Free Hospital-Nutritional Prioritizing Tool (RFH-NPT)[J]. Arq Gastroenterol, 2023, 60(1): 84-90. |
| [8] | Saeki C, Kinoshita A, Kanai T, et al. The Geriatric Nutritional Risk Index predicts sarcopenia in patients with cirrhosis[J]. Sci Rep, 2023, 13(1): 3888. |
| [9] | 苏蒙召, 吴远珏, 李玲, 等. NRS-2002与RFH-NPT在肝硬化患者中应用比较: 基于SGA标准[J]. 临床消化病杂志, 2022, 34(1): 1-6. |
| Su MZ, Wu YJ, Li L, et al. Comparison of the NRS-2002 and RFH-NPT in patients with cirrhosis: based on SGA criteria[J]. Chin J Clin Gastroenterol, 2022, 34(1): 1-6. | |
| [10] | 赵勋念, 杨杰. 肝硬化患者营养不良风险筛查及评估方法的研究进展[J]. 临床内科杂志, 2023, 40(12): 862-864. |
| Zhao XN, Yang J. Research progress on malnutrition risk screening and assessment methods in patients with cirrhosis[J]. J Clin Intern Med, 2023, 40(12): 862-864. | |
| [11] | Zhang P, Wang Q, Zhu M, et al. Differences in nutritional risk assessment between NRS2002, RFH-NPT and LDUST in cirrhotic patients[J]. Sci Rep, 2023, 13(1): 3306. |
| [12] | 中华医学会肝病学分会, 中华医学会消化病学分会. 终末期肝病临床营养指南[J]. 实用肝脏病杂志, 2019, 22(5): 624-635. |
| Chinese Society of Hepatology, Chinese Society of Gastroenterology. Clinical guidelines on nutrition in end-stage liver disease[J]. J Prac Hepatol, 2019, 22(5): 624-635. | |
| [13] | Aghemo A, Alekseeva OP, Angelico F, et al. Role of silymarin as antioxidant in clinical management of chronic liver diseases: a narrative review[J]. Ann Med, 2022, 54(1): 1548-1560. |
| [14] | 邱敏. 多学科团队协作营养管理方案在口腔癌病人中的应用[J]. 全科护理, 2023, 21(14): 1937-1940. |
| Qiu M. Application of a multidisciplinary team-based nutritional management program in patients with oral cancer[J]. Chinese General Practice Nursing, 2023, 21(14): 1937-1940. | |
| [15] | 孔凡美, 高坤范, 鲍建丽, 等. 个案管理师主导的多学科协作重症患者肠内营养管理方案的实践[J]. 现代临床护理, 2023, 22(11): 43-49. |
| Kong FM, Gao KF, Bao JL, et al. Effect of case manager led multidisciplinary management on enteral nutrition for critically ill patients[J]. Modern Clinical Nursing, 2023, 22(11): 43-49. | |
| [16] | 刘春燕, 刘婷, 黄慧. 基于营养风险等级的多学科营养管理模式在脑梗死吞咽障碍患者中的应用研究[J]. 中国当代医药, 2023, 30(25): 60-64. |
| Liu CY, Liu T, Huang H. Application of multidisciplinary nutrition management based on nutritional risk level in patients with dysphagia of cerebral infarction[J]. China Modern Medicine, 2023, 30(25): 60-64. | |
| [17] | 史志红, 周晓, 班志芬. 乙型肝炎肝硬化与酒精性肝硬化患者营养状况评估分析[J]. 实用肝脏病杂志, 2018, 21(4): 629-630. |
| Shi ZH, Zhou X, Ban ZF. Evaluation of nutritional status in patients with hepatitis B-related and alcoholic cirrhosis[J]. J Prac Hepatol, 2018, 21(4): 629-630. | |
| [18] | 王劲松, 胡鹏. 肌少症诊断研究进展[J]. 现代医药卫生, 2022, 38(19): 3335-3338. |
| Wang JS, Hu P. Advances in the diagnosis of sarcopenia[J]. J Mod Med Health, 2022, 38(19): 3335-3338. | |
| [19] | Kaplan A, Rosenblatt R. Symptom management in patients with cirrhosis: a practical guide[J]. Curr Treat Options Gastroenterol, 2022, 20(2): 144-159. |
| [20] | 张一骏, 张茜, 罗新华. 肝硬化患者营养不良和衰弱的评估与临床管理[J]. 临床肝胆病杂志, 2022, 38(7): 1646-1649. |
| Zhang YJ, Zhang Q, Luo XH. Assessment and clinical management of malnutrition and asthenia in patients with liver cirrhosis[J]. J Clin Hepatol, 2022, 38(7): 1646-1649. | |
| [21] | Haj Ali S, Abu Sneineh A, Hasweh R. Nutritional assessment in patients with liver cirrhosis[J]. World J Hepatol, 2022, 14(9): 1694-1703. |
| [22] | European Association for the Study of the Liver. EASL Clinical Practice Guidelines on the management of hepatic encephalopathy[J]. J Hepatol, 2022, 77(3): 807-824. |
| [23] | 章晓云, 邓俊黎, 张霓, 等. 失代偿期乙型病毒性肝炎肝硬化病人实施个体化蛋白质-热量饮食方案的干预研究[J]. 护理研究, 2019, 33(9): 1613-1615. |
| Zhang XY, Deng JL, Zhang N, et al. Intervention study on individualized protein-calorie diet in patients with decompensated hepatitis B cirrhosis[J]. Chinese Nursing Research, 2019, 33(9): 1613-1615. | |
| [24] | Semmler G, Datz C, Trauner M. Eating, diet, and nutrition for the treatment of non-alcoholic fatty liver disease[J]. Clin Mol Hepatol, 2023, 29(Supp1): S244-S260. |
| [25] | 郑小静, 严红虹, 甘彬, 等. 肝细胞癌患者低血糖发生率和影响因素研究[J]. 护理学报, 2022, 29(17): 43-46. |
| Zheng XJ, Yan HH, Gan B, et al. Incidence and risk factors of hypoglycemia in patients with hepatocellular carcinoma[J]. Journal of Nursing, 2022, 29(17): 43-46. | |
| [26] | 宋健, 李红亮, 戚旭飞, 等. 失代偿期乙型肝炎后肝硬化病人营养状况与预后关系的研究[J]. 肠外与肠内营养, 2018, 25(6): 346-348. |
| Song J, Li HL, Qi XF, et al. The relationship between nutritional status and prognosis of patients with decompensated hepatitis B virus-related liver cirrhosis[J]. Parenteral & Enteral Nutrition, 2018, 25(6): 346-348. | |
| [27] | Magnussen C, Ojeda FM, Leong DP, et al. Global effect of modifiable risk factors on cardiovascular disease and mortality[J]. N Engl J Med, 2023, 389(14): 1273-1285. |
| [28] | Tadokoro T, Morishita A, Himoto T, et al. Nutritional support for alcoholic liver disease[J]. Nutrients, 2023, 15(6): 1360. |
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