Journal of Internal Medicine Concepts & Practice >

2025 , Vol. 20 >Issue 05: 399 - 404

DOI: https://doi.org/10.16138/j.1673-6087.2025.05.10

Discussion on effect and mechanism of hypoglycemic drugs on Parkinson disease

  • ZHANG Haihan ,
  • JING Wei ,
  • SHAN Yuetong ,
  • ZHANG Yuling ,
  • CHEN Anan ,
  • LONG Siqi ,
  • WANG Yuze ,
  • LI Wei ,
  • PAN Weidong
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  • 1. a. Department of Neurology; b. Encephalopathy Research Laboratory, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
    2. Department of Encephalopathy I, Anhui Provincial Hospital of Integrated Chinese and Western Medicine the Third Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230031, China

Received date: 2025-09-18

  Online published: 2025-12-26

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, 2025, Copyright reserved © 2025.
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Abstract

Parkinson disease (PD) is a chronic neurodegenerative disease, and the pathgenesis is mainly related to neuronal degeneration and abnormal accumulation of αSyn. Some studies have shown that patients with PD are more likely to suffer from type 2 diabetes mellitus. Hypoglycemic drugs regulate blood glucose through modulating glucose metabolism and improving insulin sensitivity. Some of hypoglycemic drugs also have neuroprotective or antioxidant effect, and their mechanisms of action in neurodegenerative diseases have been extensively studied in recent years. This article reviews the pathological basis and related pathogenesis of PD, exploring the effect of hypoglycemic drugs on the progression of PD.

Key words： Parkinson disease; Diabetes mellitus; Hypoglycemic agent

Cite this article

ZHANG Haihan , JING Wei , SHAN Yuetong , ZHANG Yuling , CHEN Anan , LONG Siqi , WANG Yuze , LI Wei , PAN Weidong . Discussion on effect and mechanism of hypoglycemic drugs on Parkinson disease[J]. Journal of Internal Medicine Concepts & Practice, 2025 , 20(05) : 399 -404 . DOI: 10.16138/j.1673-6087.2025.05.10

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