Journal of Internal Medicine Concepts & Practice >

2025 , Vol. 20 >Issue 05: 415 - 419

DOI: https://doi.org/10.16138/j.1673-6087.2025.05.13

Advances in pathogenesis and treatment of chronic obstructive pulmonary disease complicated with sarcopenia

  • WANG Yi ,
  • HUANG Hui
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  • 1. Department of Pulmonary and Critical Care Medicine, the Sixth People’s Hospital of Kunshan, Suzhou 215300, China
    2. Department of Pulmonary Disease, Kunshan Hospital of Chinese Medicine, Suzhou 215300, China

Received date: 2024-08-13

  Online published: 2025-12-26

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, 2025, Copyright reserved © 2025.
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Abstract

Chronic obstructive pulmonary disease (COPD) is one of the most common chronic diseases of the respiratory tract, with a high mortality and disability rate. Sarcopenia is an important extrapulmonary manifestation in COPD patients, and its incidence rate is not low. The pathogenesis of COPD complicated with sarcopenia involves oxidative stress, systemic inflammatory response, autophagy, malnutrition and decreased physical activity, etc. Current research has shown that exercise intervention, nutritional support, and medication treatment can improve patients’ muscle strength and physical mobility, thereby enhancing patient prognosis. This article comprehensively reviews the pathogenesis and treatment of COPD complicated with sarcopenia, aiming to provide a valuable reference for disease research, diagnosis and treatment.

Key words： Chronic obstructive pulmonary disease; Sarcopenia; Pathogenesis; Epidemiology

Cite this article

WANG Yi , HUANG Hui . Advances in pathogenesis and treatment of chronic obstructive pulmonary disease complicated with sarcopenia[J]. Journal of Internal Medicine Concepts & Practice, 2025 , 20(05) : 415 -419 . DOI: 10.16138/j.1673-6087.2025.05.13

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