Journal of Internal Medicine Concepts & Practice >

2026 , Vol. 20 >Issue 06: 435 - 439

DOI: https://doi.org/10.16138/j.1673-6087.2025.06.02

Relationship between triglyceride-glucose index and risk of acute myocardial infarction in patients with atrial fibrillation

  • CHEN Liangguo ,
  • DENG Kewu ,
  • LIU Yue ,
  • ZHONG Peng ,
  • BAI Ying
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  • 1. Cardiovascular Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100005, China
    2. Department of Cardiology,the First Affiliated Hospital of Harbin Medical University, Harbin 150007, China
    3. Department of Ultrasound Diagnosis, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China

Received date: 2024-08-21

  Online published: 2026-01-30

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, 2025, Copyright reserved © 2025.
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Abstract

Objective To explore the relationship between triglyceride-glucose (TyG) index and the occurrence of acute myocardial infarction (AMI) in patients with atrial fibrillation (AF). Methods A total of 4 277 hospitalized AF patients from Beijing Tongren Hospital and Beijing Friendship Hospital affiliated to Capital Medical University were enrolled. They were divided into a non-AMI group [AMI(−), 3 725 cases] and an AMI group [AMI(+), 552 cases] based on whether they were admitted for AMI. Logistic regression was used to assess the association between the TyG index and AMI, and subgroup analyses were performed according to the presence of diabetes at baseline. Results Among AF patients, the TyG index was significantly higher in the AMI(+) group than in the AMI(−) group (8.83 ± 0.73 vs. 8.56 ± 0.66, P < 0.001). Additionally, patients in the AMI(+) group were older and had more comorbidities (both P < 0.05). Multivariate Logistic regression showed that high TyG index was an independent risk factor for AMI in AF patients [odds ratio(OR) = 1.824, 95%CI 1.540−2.161, P < 0.001], and the area under the receiver operating characteristic (ROC) curve for the TyG index in predicting AMI was 0.614 (95%CI 0.589−0.640, P < 0.001), with a cut-off value of 8.79. In AF patients, the TyG index was positively associated with the risk of AMI regardless of the presence of diabetes. Conclusions The TyG index is positively associated with the risk of AMI in AF patients, which is not affected by diabetes status.

Key words： Triglyceride-glucose index; Atrial fibrillation; Acute myocardial infarction

Cite this article

CHEN Liangguo , DENG Kewu , LIU Yue , ZHONG Peng , BAI Ying . Relationship between triglyceride-glucose index and risk of acute myocardial infarction in patients with atrial fibrillation[J]. Journal of Internal Medicine Concepts & Practice, 2026 , 20(06) : 435 -439 . DOI: 10.16138/j.1673-6087.2025.06.02

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