蛋白质赖氨酸甲基转移酶在甲状腺癌中的研究进展
收稿日期: 2023-11-13
网络出版日期: 2024-03-04
基金资助
国家自然科学基金(81972496);2020年度黄浦区领军人才计划;共青团上海交通大学医学院委员会“甲状腺肿瘤防治”青年科技创新工作室
Advances of protein lysine methyltransferases in thyroid carcinoma
Received date: 2023-11-13
Online published: 2024-03-04
蛋白质赖氨酸甲基转移酶（protein lysine methyltransferase, PKMT）能催化组蛋白尾部和非组蛋白靶标上的赖氨酸残基甲基化。这类重要的翻译后修饰，可影响染色质的结构和紧密程度，进而影响基因表达。越来越多证据表明，PKMT的遗传改变会影响PKMT在组织中的正常表达从而发挥致癌或抑癌功能。在多种实体瘤中发现PKMT的表达与肿瘤病人的预后有关。本综述总结Zeste增强子同源物2（enhancer of zeste homologue 2, EZH2）、组蛋白-赖氨酸N-甲基转移酶2（histone-lysine N-methyltransferase 2, KMT2）家族和含有SET结构域及MYND结构域蛋白（SET and MYND domain-containing protein, SMYD）家族三类主要PKMT的功能及其在甲状腺癌中的作用。
何熹, 史苑, 钱凯, 王卓颖 . 蛋白质赖氨酸甲基转移酶在甲状腺癌中的研究进展[J]. 外科理论与实践, 2023 , 28(06) : 563 -567 . DOI: 10.16139/j.1007-9610.2023.06.013
Protein lysine methyltransferases (PKMT) catalyze methylation of lysine residues on histone tails and non-histone targets. These important post-translational modifications affect the structure and compactness of chromatin, which in turn affects gene expression. There is growing evidence that genetic alterations in PKMT affect the normal expression of PKMT in tissues and thus exert oncogenic or tumor suppressor functions. The expression of PKMT has been found to be associated with the prognosis of tumor patients in a variety of solid tumors. In this review, we summarized the functions of three major PKMT, including EZH2, KMT2 family and SMYD family, and their roles in thyroid carcinoma.
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