多倍体肝细胞的生理功能及其病理性改变的相关疾病
收稿日期: 2023-10-08
网络出版日期: 2024-03-04
基金资助
国家自然科学基金(82372603);国家自然科学基金(82172900);国家自然科学基金(81602544);希思科—朝阳肿瘤研究基金(Y-Young2021-0015);上海市教育委员会高峰高原计划-交医“双百人”研究型医师项目(20191901)
Physiological function of polyploid hepatocytes and pathological changes in its associated diseases
Received date: 2023-10-08
Online published: 2024-03-04
张亦凡, 鲁逸权, 郝风节, 王俊青 . 多倍体肝细胞的生理功能及其病理性改变的相关疾病[J]. 外科理论与实践, 2023 , 28(06) : 574 -579 . DOI: 10.16139/j.1007-9610.2023.06.015
Liver is a unique organ with polyploidy. About 20 to 50 percent of hepatocytes in adult human are polyploid cells, which contain more than two sets of chromosomes. Hepatocytes polyploidization is triggered by the changes in insulin signal during weaning, and regulated by various cell cycle regulator genes to ensure the polyploid cells proportion, ploidy and zonation. The regulation of polyploid hepatocytes is crucial for liver's metabolic and regenerative function, and protecting liver from tumorigenesis. However, in chronic virus hepatitis and nonalcoholic fatty liver disease, the pathological hepatocytes polyploidization can be found in disease progression because of cell cycle checkpoint inhibition and oxidative stress. Distinguishing physiological and pathological hepatocyte polyploidization will be helpful for the understanding the relationship between chronic liver disease and tumorigenesis.
Key words： Ploidy; Polyploidy; Chromosomal instability; Hepatocyte; Hepatocellular carcinoma
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