外科理论与实践

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2024 , Vol. 29 >Issue 02: 126 - 131

DOI: https://doi.org/10.16139/j.1007-9610.2024.02.06

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肝脏微环境细胞对结肠直肠癌肝转移的作用

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  • 复旦大学附属肿瘤医院肝脏外科，上海 200032
*: 共同第一作者
王鲁，E-mail：wangluzl@fudan.edu.cn

收稿日期: 2024-03-15

  网络出版日期: 2024-07-01

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The role of liver microenvironment cells in colorectal cancer liver metastasis

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  • Department of Hepatic Surgery, Fudan University, Shanghai Cancer Center, Shanghai 200032, China

Received date: 2024-03-15

  Online published: 2024-07-01

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摘要

肝脏是结肠直肠癌最常见的转移部位。肝脏微环境包含了复杂的细胞群体，每种细胞都具备独特的生物学特性和功能，辅以细胞之间的交互作用，共同调节肿瘤微环境，对结肠直肠癌肝转移的发生和发展起到关键作用。深入探索结肠直肠肝转移相关的分子机制，对于理解肿瘤进展、预测转移风险以及开发新的治疗策略至关重要。本文重点从肝脏肿瘤微环境的细胞组成角度出发，探讨了不同细胞类型在肠癌肝转移过程中的作用和影响，旨在为结肠直肠癌肝转移的诊疗提供新的视角和思路。

关键词： 结肠直肠癌肝转移; 肿瘤微环境; 肝星状细胞; 肝窦内皮细胞; 库普弗细胞; 中性粒细胞; 巨噬细胞; 髓源性抑制细胞

本文引用格式

赵一鸣, 吴棕, 王鲁 . 肝脏微环境细胞对结肠直肠癌肝转移的作用[J]. 外科理论与实践, 2024 , 29(02) : 126 -131 . DOI: 10.16139/j.1007-9610.2024.02.06

Abstract

The liver is the most common site of metastasis in patients with colorectal cancer(CRC). The liver microenvironment is a diverse assemblage of cells, which has their own unique biological characteristics and functions, supplemented by the interaction between cells, which jointly regulate the tumor microenvironment and play significant role in the occurrence and development of CRC liver metastasis. Consequently, a thorough investigation of the molecular mechanisms underlying CRC liver metastasis is imperative for comprehension of tumor progression, prediction of metastasis risk, and the development of innovative therapeutic strategy. This paper delved into the cellular constituents of the liver tumor microenvironment, elucidating the roles and influences of diverse cell types in the process of CRC liver metastasis, offering fresh insights and strategies for the diagnosis and management of CRC liver metastasis.

Key words： Colorectal cancer liver metastasis; Tumor microenvironment; Hepatic stellate cell(HepSC); Liver sinusoidal endothelial cell(LSEC); Kupffer cell(KC); Neutrophil; Macrophage; Myeloid-derived suppressor cell(MDSC)

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