专家论坛

甲状腺滤泡性肿瘤超声诊断新进展

  • 苏一轩 ,
  • 应涛
展开
  • 上海交通大学医学院附属第六人民医院超声医学科 上海超声医学研究所,上海 200233
应涛,E-mail:yingtaomail@yeah.net

收稿日期: 2024-12-03

  网络出版日期: 2025-04-25

Recent advances in ultrasound diagnosis of thyroid follicular neoplasms

  • SU Yixuan ,
  • YING Tao
Expand
  • Department of Ultrasound in Medicine, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Institute of Ultrasound in Medicine, Shanghai 200233, China

Received date: 2024-12-03

  Online published: 2025-04-25

摘要

常规超声影像对于甲状腺滤泡性肿瘤的良、恶性鉴别较为困难,主要依赖于术后病理诊断。超声新技术和人工智能的进步,在提高诊断准确性、减少不必要手术和降低误诊率方面展现了较大潜力。超声超微血流成像、超声造影及超声弹性成像等新技术,为甲状腺滤泡性肿瘤术前良、恶性鉴别诊断提供了新的途径。本文总结并探讨了上述超声新技术及基于人工智能的多种建模方法在甲状腺滤泡性肿瘤术前诊断中的应用价值,以期为临床决策提供科学依据。

本文引用格式

苏一轩 , 应涛 . 甲状腺滤泡性肿瘤超声诊断新进展[J]. 外科理论与实践, 2025 , 30(01) : 21 -26 . DOI: 10.16139/j.1007-9610.2025.01.05

Abstract

Conventional ultrasonography often struggles to accurately differentiate between benign and malignant thyroid follicular tumors, which relying heavily on postoperative pathological diagnosis. Recent advancements in novel ultrasound technologies and artificial intelligence(AI) have shown significant potential in improving diagnostic accuracy, reducing unnecessary surgeries, and decreasing misdiagnosis rates. Emerging ultrasound modalities, such as superb microvascular imaging, contrast-enhanced ultrasound, and ultrasound elastography, provide new approaches for preoperative differentiation of thyroid follicular tumors. This review summarized and discussed the application value of these novel ultrasound techniques and various AI-based modeling methods in the preoperative diagnosis of thyroid follicular tumors, aiming to provide a scientific basis for clinical decision-making.

参考文献

[1] HADDAD R I, NASR C, BISCHOFF L, et al. NCCN guidelines insights: thyroid carcinoma, version 2.2018[J]. J Natl Compr Canc Netw, 2018, 16(12):1429-1440.
[2] 中华医学会超声医学分会浅表器官和血管学组, 中国甲状腺与乳腺超声人工智能联. 2020甲状腺结节超声恶性危险分层中国指南:C-TIRADS[J]. 中华超声影像学杂志, 2021, 30(3):185-200.
  Superficial Organ and Vascular Ultrasound Group, Society of Ultrasound in Medicine, Chinese Medical Association; Chinese Artificial Intelligence Alliance for Thyroid and Breast Ultrasound. 2020 Chinese guidelines for ultrasound malignancy risk stratification of thyroid nodules:the C-TIRADS[J]. Chin J Ultrasonogr, 2021, 30(3):185-200.
[3] 李婷, 陈露, 李媛, 等. 甲状腺滤泡性腺瘤与滤泡癌的超声检查特征分析[J]. 医学影像学杂志, 2024, 34(8):30-32.
  LI T, CHEN L, LI Y, et al. Analysis of ultrasound characteristics of thyroid follicular adenoma and follicular carcinoma[J]. J Med Imaging, 2024, 34(8):30-32.
[4] HAYASHI C Y, JAUNE D T A, OLIVEIRA C C, et al. Indeterminate thyroid cytology: detecting malignancy using analysis of nuclear images[J]. Endocr Connect, 2021, 10(7):707-714.
[5] GRANI G, LAMARTINA L, DURANTE C, et al. Follicular thyroid cancer and Hürthle cell carcinoma: challenges in diagnosis, treatment, and clinical management[J]. Lancet Diabetes Endocrinol, 2018, 6(6):500-514.
[6] WILHELM A, CONROY P C, CALTHORPE L, et al. Disease-specific survival trends for patients presenting with differentiated thyroid cancer and distant metastases in the United States, 1992-2018[J]. Thyroid, 2023, 33(1):63-73.
[7] 唐婉晴, 张晓娟, 姜丹妮, 等. 甲状腺滤泡癌与滤泡腺瘤的超声特征分析[J]. 临床医学进展, 2022, 12(4):3724-3732.
  TANG W Q, ZHANG X J, JIANG D N, et al. Sonographic characteristics and differentiation of follicular thyroid carcinoma and follicular adenoma[J]. Adv Clin Med, 2022, 12(4):3724-3732.
[8] KOIKE E, NOGUCHI S, YAMASHITA H, et al. Ultrasonographic characteristics of thyroid nodules: prediction of malignancy[J]. Arch Surg, 2001, 136(3):334-337.
[9] 中华人民共和国国家卫生健康委员会医政医管局. 甲状腺癌诊疗指南(2022年版)[J]. 中国实用外科杂志, 2022, 42(12):1343-1357,1363.
  National Health Commission of the People’s Republic of China Medical Administration and Hospital Administration. Guidelines for the diagnosis and treatment of thyroid carcinoma[J]. Chin J Pract Surg, 2022, 42(12):1343-1357,1363.
[10] 谢文婷, 陈轶洁, 黄伟钦, 等. 甲状腺滤泡癌与腺瘤的超声声像比较研究[J]. 肿瘤, 2020, 40(5):348-354.
  XIE W T, CHEN Y J, HUANG W Q, et al. Comparative study of ultrasound imaging of thyroid follicular carcinoma and adenoma[J]. Tumor, 2020, 40(5):348-354.
[11] KUO T C, WU M H, CHEN K Y, et al. Ultrasonographic features for differentiating follicular thyroid carcinoma and follicular adenoma[J]. Asian J Surg, 2020, 43(1):339-346.
[12] XU R, WEN W, ZHANG Y, et al. Diagnostic significance of ultrasound characteristics in discriminating follicular thyroid carcinoma from adenoma[J]. BMC Med Imaging, 2024, 24(1):299.
[13] OU D, YAO J, JIN J, et al. Ultrasonic identification and regression analysis of 294 thyroid follicular tumors[J]. J Cancer Res Ther, 2020, 16(5):1056-1062.
[14] ZHANG F, MEI F, CHEN W, et al. Role of ultrasound and ultrasound‐based prediction model in differentiating follicular thyroid carcinoma from follicular thyroid adenoma[J]. J Ultrasound Med, 2024, 43(8):1389-1399.
[15] LIU B J, ZHANG Y F, ZHAO C K, et al. Conventional ultrasound characteristics, TI-RADS category and shear wave speed measurement between follicular adenoma and follicular thyroid carcinoma[J]. Clin Hemorheol Microcirc, 2020, 75(3):291-301.
[16] LI H J, YANG Y P, LIANG X, et al. Comparison of the diagnostic performance of three ultrasound thyroid no-dule risk stratification systems for follicular thyroid neoplasm: K-TIRADS, ACR-TIRADS and C-TIRADS[J]. Clin Hemorheol Microcirc, 2023, 85(4):395-406.
[17] LI J, LI C, ZHOU H, et al. US risk stratification system for follicular thyroid neoplasms[J]. Radiology, 2023, 309(2):e230949.
[18] KONG J, LI J C, WANG H Y, et al. Role of superb micro-vascular imaging in the preoperative evaluation of thyroid nodules: comparison with power Doppler flow imaging[J]. J Ultrasound Med, 2017, 36(7):1329-1337.
[19] 王莹, 张岱, 杨凡, 等. 超微血流显像与超声造影对甲状腺实性结节的诊断价值[J]. 中国肿瘤临床, 2021, 48(14):711-715.
  WANG Y, ZHANG D, YANG F, et al. The diagnostic value of superb micro-vacular imaging and contrast-enhanced ultrasound in solid thyroid nodules[J]. Chin J Clin Oncol, 2021, 48(14):711-715.
[20] 江琼, 林友国. 甲状腺滤泡状腺癌与良性结节的超声鉴别诊断[J]. 实用医学影像杂志, 2023, 24(3):221-225.
  JIANG Q, LIN Y G. Ultrasonographic differential diagnosis of follicular thyroid carcinoma and thyroid benign nodule[J]. J Pract Med Imaging, 2023, 24(3):221-225.
[21] 邬宏恂, 王隽. 甲状腺滤泡状癌声像图分析[J]. 临床超声医学杂志, 2007, 9(9):535-538.
  WU H X, WANG J. Analysis of ultrasonographic imaging in thyroid follicular carcinoma[J]. J Ultrasound in Clin Med, 2007, 9(9):535-538.
[22] CANNELLA R, PILATO G, MAZZOLA M, et al. New microvascular ultrasound techniques: abdominal applications[J]. Radiol Med, 2023, 128(9):1023-1034.
[23] ZHAO W, LU R, YIN L, et al. The value of superb microvascular imaging (SMI) scoring assignment method in differentiating benign and malignant thyroid nodules by conventional ultrasound[J]. Clin Hemorheol Microcirc, 2021, 78(4):355-363.
[24] BOJUNGA J, TRIMBOLI P. Thyroid ultrasound and its ancillary techniques[J]. Rev Endocr Metab Disord, 2024, 25(1):161-173.
[25] GAO W, CHEN Y, WU Q, et al. Significance of maximum intensity projection technique of multimodal ultrasound imaging in differentiating follicular thyroid carcinoma from benign lesions[J]. Front Oncol, 2024,14:1407611.
[26] WU Q, QU Y, LI Y, et al. Logistic regression analysis of contrast-enhanced ultrasound and conventional ultrasound of follicular thyroid carcinoma and follicular adenoma[J]. Gland Surg, 2021, 10(10):2890-2900.
[27] DIAO X H, CHEN L, YU B, et al. Follicular thyroid neoplasm on conventional and contrast-enhanced ultrasound[J]. Adv Ultrasound Diagn Ther, 2022, 6(2):48-57.
[28] 李诗骜, 陆鑫, 姜珏, 等. 超声造影鉴别甲状腺滤泡状肿瘤及其与年龄、性别的相关性分析[J]. 中国临床医学影像杂志, 2023, 34(1):15-18.
  LI S A, LU X, JIANG J, et al. Contrast-enhanced ultrasound in the differential diagnosis of follicular thyroid tumor and its correlation with age and gender[J]. J Chin Clin Med Imaging, 2023, 34(1):15-18.
[29] YOO M H, KIM H J, CHOI I H, et al. Efficacy of differential diagnosis of thyroid nodules by shear wave elastography—the stiffness map[J]. J Endocr Soc, 2021, 5(11):bvab154.
[30] COSGROVE D, BARR R, BOJUNGA J, et al. WFUMB guidelines and recommendations on the clinical use of ultrasound elastography: part 4. thyroid[J]. Ultrasound Med Biol, 2017, 43(1):4-26.
[31] 李宁, 杨丽春, 王丽伟, 等. 声辐射力弹性成像联合超声造影对甲状腺滤泡型肿瘤的诊断价值[J]. 放射学实践, 2020, 35(5):663-667.
  LI N, YANG C L, WANG L W, et al. The diagnostic value of acoustic radiation force elastography combined with contrast-enhanced ultrasound in thyroid follicular tumor[J]. Radiol Pract, 2020, 35(5):663-667.
[32] SOLOMON C, PETEA-BALEA D R, DUDEA S M, et al. Role of ultrasound elastography and contrast-enhanced ultrasound (CEUS) in diagnosis and management of malignant thyroid nodules—an update[J]. Diagnostics(Basel), 2025, 15(5):599.
[33] SHIN I, KIM Y J, HAN K, et al. Application of machine learning to ultrasound images to differentiate follicular neoplasms of the thyroid gland[J]. Ultrasonography, 2020, 39(3):257-265.
[34] CHEN W, NI X J, QIAN C, et al. The value of a neural network based on multi-scale feature fusion to ultrasound images for the differentiation in thyroid follicular neoplasms[J]. BMC Med Imaging, 2024, 24(1):74.
[35] ZHENG Y, ZHANG Y J, LU K F, et al. Diagnostic value of an interpretable machine learning model based on clinical ultrasound features for follicular thyroid carcinoma[J]. Quant Imaging Med Surg, 2024, 14(9):6311-6324.
文章导航

/