Advances in the concomitant chronic liver disease and colorectal cancer liver metastasis

doi:10.16139/j.1007-9610.2025.04.12

Abstract

Abstract:

Liver metastasis is a key factor contributing to the poor prognosis of patients with colorectal cancer (CRC), and chronic liver diseases promote the occurrence and development of CRC liver metastasis (CRLM) through various mechanisms such as altering the tumor microenvironment (TME). This article reviewed the association of chronic liver diseases, such as chronic hepatitis B (CHB), non-alcoholic fatty liver disease (NAFLD), alcoholic liver disease (ALD), drug-induced liver injury (DILI), with CRLM. It briefly reviewed recent epidemiological trends of these chronic liver diseases. Furthermore, the relationship between chronic liver diseases and CRLM is elaborated from the aspects of risk factors, pathogenic mechanisms, and management. The mechanisms by which these chronic liver diseases affect CRLM are explored.

Key words: Colorectal cancer(CRC), Liver metastasis, Chronic liver disease, Tumor microenvironment (TME)

CLC Number:

YANG Yue, ZHAO Lei. Advances in the concomitant chronic liver disease and colorectal cancer liver metastasis[J]. Journal of Surgery Concepts & Practice, 2025, 30(04): 364-368.

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