Objective: To investigate the prevalence of gallbladder stone disease(GSD) in Shanghai and analyze the risk factors associated with GSD. Methods: The cross-section survey was carried out from August 2010 to July 2011. We enrolled 15 256 habitants in three districts of Shanghai (8 617 male and 6 639 female), aged between 20-79 years old. The relevant clinical data of the subjects were collected by questionnaire, physical examination and biochemical analysis. GSD was diagnosed by type-B ultrasonography. T test and Logistic stepwise regression were performed to analyze the risk factors associated with GSD. Results: ① The prevalence of GSD was 7.02% in this survey, which was slight higher in females than in males (8.10% vs 6.19%, P<0.05) and increased with age (P<0.05). ② The rate of cholecystectomy was 2.48% in total, almost twice in females than in males (3.42% vs 1.75%, P<0.05), and increased with age as well (P<0.05). ③ Logistic stepwise regression analysis showed that female, older, presence of fatty liver disease, family history, hypertension and increased body mass index (BMI) were the risk factors for GSD. Conclusions: Our survey showed that the prevalence of GSD was 7.02% and the cholecystectomy rate was 2.48% in Shanghai population. Gender, age, fatty liver disease, family history, hypertension and BMI were the risk factors associated with GSD.
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