Objective: To evaluate the expression of adaptor protein Crk in gastric cancer and the associations with clinicopathological characteristics and prognosis of gastric cancer. Methods: The expression of Crk protein of matched tumor and adjacent tissues in 368 patients with gastric cancer was analyzed by immunohistochemistry. The relation of Crk protein expression with clinicopathological characteristics and clinical outcome was evaluated. Results: Compared with adjacent non-tumor tissues, Crk protein was significantly up-regulated in tumor tissues (P<0.05). An elevated Crk protein expression statistically related with aggressive clinicopathological characteristics significantly including larger tumor size (P<0.05), deeper local invasion (P<0.05), more lymph node metastasis (P<0.05) and advanced TNM stage (P<0.05). Gastric cancer patients with higher expression of Crk protein had poorer prognosis (P<0.05). Multivariate analysis showed that higher level of Crk protein was an independent unfavorable prognostic factor of gastric cancer. Conclusions: Crk protein may be associated with tumor progression in gastric cancer and may predict unfavorable prognosis of gastric cancer as a novel molecular marker.
FENG Runhua, SAH K. Birendra, LU Sheng, YUAN Fei, XU Haimin, LIU Bingya, YAN Min, LI Chen, ZHU Zhenggang
. Clinical significance of Crk expression in gastric cancer[J]. Journal of Surgery Concepts & Practice, 2018
, 23(03)
: 258
-262
.
DOI: 10.16139/j.1007-9610.2018.03.015
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