Objective: To assess the safety and effectiveness of preliver transplantation transarterial chemoembolization (TACE) in hepatocellular carcinoma (HCC) beyond UCSF criteria. Methods: We retrospectively analyzed the clinical data of 83 patients with HCC beyond UCSF criteria, who were divided into TACE group and control group. The postoperative acute rejection, biliary complications, vascular complications, tumor free survival rate and overall survival rate between two groups were compared. Results: There were (2.0±1.3) preliver transplantation TACE procedures with the period of (15.7±8.4) d between final TACE treatment and liver transplantation. There was no significant difference in postoperative acute rejection, biliary complications and hepatic artery embolism between TACE group and control group(P>0.05). The tumor free survival rate and overall survival rate in TACE group were significantly higher than those in control group (P<0.05). Stratification analysis revealed that the 1-, 3-, 5-year tumor free survival rate and overall survival rate of the patients with complete response or partial response were much higher than those of the patients without response(P<0.05). The 1-, 3-, 5-year tumor free survival rate and overall survival rate were significantly higher in the patients with HCC which satisfied UCSF criteria after TACE than those in the patients with HCC still beyond UCSF criteria(P<0.05). Conclusions: Preliver transplantation TACE can prolong tumor free survival time and overall survival time, and is safe with only one case of hepatic artery embolism.
TONG Hui, ZHANG Jiaqiang, ZHU Zhecheng, PENG Chenghong, LI Tao
. Effectiveness of preliver transplantation transarterial chemoembolization therapy in treatment of hepatocellular carcinoma beyond UCSF criteria[J]. Journal of Surgery Concepts & Practice, 2018
, 23(03)
: 241
-246
.
DOI: 10.16139/j.1007-9610.2018.03.012
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